PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease. (Q35052819)

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1 February 2020

title

PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease (English)

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1 February 2020

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Joerg T. Epplen

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author name string

Elahe Taherzadeh-Fard

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Denis A Akkad

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Stefan Wieczorek

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Aiden Haghikia

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Andrew Chan

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Larissa Arning

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publication date

19 May 2011

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Molecular Neurodegeneration

1 February 2020

published in

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volume

6

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issue

1

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page(s)

32

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Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease.

1 February 2020

cites work

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Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

8 July 2018

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The role of PGC-1α in the pathogenesis of neurodegenerative disorders

8 July 2018

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Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

8 July 2018

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Huntington's disease: the case for genetic modifiers

8 July 2018

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Impaired PGC-1alpha function in muscle in Huntington's disease.

8 July 2018

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The biology of PGC-1α and its therapeutic potential

8 July 2018

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The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

8 July 2018

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ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease.

8 July 2018

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Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease

8 July 2018

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Targeting PGC-1 alpha to control energy homeostasis

8 July 2018

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NRF-2 transcription factor is required for human TOMM20 gene expression.

8 July 2018

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Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds.

8 July 2018

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Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes

8 July 2018

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

8 July 2018

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

8 July 2018

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Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

8 July 2018

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Quantitative analysis of circulating mitochondrial DNA in plasma

8 July 2018

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Nuclear activators and coactivators in mammalian mitochondrial biogenesis

8 July 2018

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The structure of haplotype blocks in the human genome

8 July 2018

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Physical activity as a metabolic stressor

8 July 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

8 July 2018

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The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

8 July 2018

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Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

8 July 2018

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Trinucleotide repeat length instability and age of onset in Huntington's disease

8 July 2018

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NR2A and NR2B receptor gene variations modify age at onset in Huntington disease

8 July 2018

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PGC-1alpha as modifier of onset age in Huntington disease

21 January 2018

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Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

21 January 2018

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Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

21 January 2018

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Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1.

25 October 2018

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Mitochondrial haplogroup H correlates with ATP levels and age at onset in Huntington disease.

25 October 2018

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NRF-1 genotypes and endurance exercise capacity in young Chinese men.

25 October 2018

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25 October 2018

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New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes

25 October 2018

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PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men

25 October 2018

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Mitochondrial haplogroup T is negatively associated with the status of elite endurance athlete

9 December 2018

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12 December 2020

Genetic Variations inPPARDandPPARGC1ADetermine Mitochondrial Function and Change in Aerobic Physical Fitness and Insulin Sensitivity during Lifestyle Intervention

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12 December 2020

[Association of the mitochondrial transcription factor (TFAM) gene polymorphism with physical performance of athletes]

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12 December 2020

NRF2 genotype improves endurance capacity in response to training

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12 December 2020

Identifiers

DOI

10.1186/1750-1326-6-32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21595933%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 February 2020

0 references

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1 February 2020

PubMed publication ID

21595933

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