Targeting PGC-1 alpha to control energy homeostasis (Q36956731)

17 August 2017

1 reference

title

Targeting PGC-1 alpha to control energy homeostasis (English)

1 reference

17 August 2017

Zhidan Wu

1

1 reference

PubMed ID

17907962

17 August 2017

Olivier Boss

series ordinal

2

1 reference

PubMed ID

17907962

17 August 2017

language of work or name

English

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publication date

1 October 2007

1 reference

Expert Opinion on Therapeutic Targets

17 August 2017

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17 August 2017

11

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17 August 2017

10

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17 August 2017

1329-1338

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Unraveling the causes of diabetes

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Etiology of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Cellular mechanisms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Obesity-induced inflammatory changes in adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Mitochondrial dysfunction and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Metabolic control through the PGC-1 family of transcription coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

The role of AMP-activated protein kinase in mitochondrial biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PGC-1alpha) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Nuclear receptor signaling and cardiac energetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Mitochondrial energy metabolism in heart failure: a question of balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Increased expression of estrogen-related receptor alpha (ERRalpha) is a negative prognostic predictor in human prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Calorie restriction--the SIR2 connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Reactive oxygen species have a causal role in multiple forms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

Expression of the thermogenic nuclear hormone receptor coactivator PGC-1α is reduced in the adipose tissue of morbidly obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1329

10.1517/14728222.11.10.1329

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

17907962