Selecting protein tyrosine phosphatases as drug targets (Q35053180)

6 August 2017

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title

Selecting protein tyrosine phosphatases as drug targets (English)

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Rob Hooft van Huijsduijnen

6 August 2017

series ordinal

1

object named as

Rob Hooft van Huijsduijnen

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6 August 2017

Agnes Bombrun

2

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PubMed ID

12546919

6 August 2017

Dominique Swinnen

series ordinal

3

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6 August 2017

1 October 2002

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6 August 2017

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6 August 2017

7

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6 August 2017

19

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6 August 2017

1013-1019

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Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Pulling strings below the surface: hormone receptor signaling through inhibition of protein tyrosine phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

PTP1B regulates leptin signal transduction in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Modulation of insulin signaling by protein tyrosine phosphatases.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

PTEN mutations in gliomas and glioneuronal tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

PTEN, a unique tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Protein tyrosine phosphatases: prospects for therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

New insights into the transmembrane protein tyrosine phosphatase CD45.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

CD45: new jobs for an old acquaintance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Phosphatases and kinases delivered to the host cell by bacterial pathogens

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Leaky vessels? Call Ang1!

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

PTP-epsilon, a tyrosine phosphatase expressed in endothelium, negatively regulates endothelial cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Introduction: phosphatases in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

The T-cell protein tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Extracellular signals and scores of phosphatases: all roads lead to MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Lipid phosphatases in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Antisense oligodeoxynucleotide evidence that a unique osteoclastic protein-tyrosine phosphatase is essential for osteoclastic resorption.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

A phosphatase associated with metastasis of colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

CDC25 phosphatases as potential human oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Expression of protein tyrosine phosphatases and its significance in esophageal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in receptor protein tyrosine phosphatase sigma knock-out mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Protein tyrosine phosphatases: counting the trees in the forest

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Structural and evolutionary relationships among protein tyrosine phosphatase domains

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Expanding small RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Effective expression of small interfering RNA in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

Metastasis in colorectal cancer associated with phosphatase expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902438-8

7 January 2021

10.1016/S1359-6446(02)02438-8

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12546919