Random mutagenesis in the mouse as a tool in drug discovery (Q35053230)

6 August 2017

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title

Random mutagenesis in the mouse as a tool in drug discovery (English)

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6 August 2017

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Andreas Russ

1

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6 August 2017

Gabriele Stumm

2

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6 August 2017

Martin Augustin

3

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6 August 2017

Reinhard Sedlmeier

4

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6 August 2017

Sigrid Wattler

5

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6 August 2017

Michael Nehls

6

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6 August 2017

1 December 2002

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6 August 2017

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6 August 2017

7

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6 August 2017

23

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6 August 2017

1175-1183

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Drugs from emasculated hormones: the principle of syntopic antagonism

6 August 2017

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Initial sequencing and analysis of the human genome

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

The Sequence of the Human Genome

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Transgenic knockouts as part of high-throughput, evidence-based target selection and validation strategies

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Mouse ENU mutagenesis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Genome-wide ENU mutagenesis to reveal immune regulators

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Suppression of body fat accumulation in myostatin-deficient mice

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Systematic approaches to mouse mutagenesis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

ENU mutagenesis: analyzing gene function in mice

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Effects of ENU dosage on mouse strains

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Sequence-based analysis of mutagenized mice

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

A gene-driven approach to the identification of ENU mutants in the mouse

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Integrated platform for detection of DNA sequence variants using capillary array electrophoresis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Mutations affecting segment number and polarity in Drosophila

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Genetic control of the cell division cycle in yeast

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

A receptor-mediated pathway for cholesterol homeostasis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Genetics of body-weight regulation

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

A frameshift mutation in MC4R associated with dominantly inherited human obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Capitalizing on large-scale mouse mutagenesis screens

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Genetics of signal transduction in invertebrates

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

A physical map of the mouse genome

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902515-1

7 January 2021

10.1016/S1359-6446(02)02515-1

Identifiers

DOI

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6 August 2017

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