Emerging therapeutic targets in chronic heart failure: part II. (Q35056026)

6 August 2017

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title

Emerging therapeutic targets in chronic heart failure: part II. (English)

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6 August 2017

main subject

chronic heart failure

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Volker Roenicke

1

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6 August 2017

Stéphane Leclair

2

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6 August 2017

Anke Hoffmann

3

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6 August 2017

Michael Becker

4

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6 August 2017

Tania Szado

5

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6 August 2017

Thomas Kirsch

6

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6 August 2017

Oliver Stoss

7

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6 August 2017

Barbara T Navé

8

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6 August 2017

Thomas Henkel

9

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6 August 2017

language of work or name

English

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publication date

1 February 2003

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Expert Opinion on Therapeutic Targets

6 August 2017

published in

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6 August 2017

volume

7

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6 August 2017

issue

1

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6 August 2017

page(s)

49-59

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Signaling pathways for cardiac hypertrophy and failure

6 August 2017

cites work

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21 January 2018

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Validation of targets and drug candidates in an engineered three-dimensional cardiac tissue model

21 January 2018

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A novel role for STAT3 in cardiac remodeling

21 January 2018

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Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy

21 January 2018

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The role of interleukin-6 in the failing heart

21 January 2018

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gp130 plays a critical role in pressure overload-induced cardiac hypertrophy

21 January 2018

1 reference

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Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways

21 January 2018

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Left ventricular remodeling after myocardial infarction: pathophysiology and therapy

21 January 2018

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Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective

21 January 2018

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Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy

21 January 2018

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Mitochondrial abnormalities in myocardium of dogs with chronic heart failure

21 January 2018

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Molecular mechanisms of apoptosis in the cardiac myocyte

21 January 2018

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Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

21 January 2018

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Losing heart: the role of apoptosis in heart disease--a novel therapeutic target?

21 January 2018

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Blocking caspase-activated apoptosis improves contractility in failing myocardium

21 January 2018

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From bench to clinic with apoptosis-based therapeutic agents

21 January 2018

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ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

21 January 2018

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Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes

21 January 2018

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ErbB2 is essential in the prevention of dilated cardiomyopathy.

21 January 2018

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Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

21 January 2018

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Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells

21 January 2018

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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

21 January 2018

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An improved plasmid DNA expression vector for direct injection into skeletal muscle

21 January 2018

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Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

21 January 2018

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Ultrarapid, highly efficient viral gene transfer to the heart

21 January 2018

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21 January 2018

Myocardial gene therapy

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Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation

21 January 2018

1 reference

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Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

21 January 2018

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Modulation of ventricular function through gene transfer in vivo

21 January 2018

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Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice

21 January 2018

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Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart

21 January 2018

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Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia

21 January 2018

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Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease

21 January 2018

1 reference

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Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure

21 January 2018

1 reference

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Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

21 January 2018

1 reference

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Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery

21 January 2018

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Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion

21 January 2018

1 reference

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Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

The Genetic Basis for Cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels: a novel strategy to manipulate excitability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Myocyte proliferation in end-stage cardiac failure in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Evidence that human cardiac myocytes divide after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Aging, cardiac hypertrophy and ischemic cardiomyopathy do not affect the proportion of mononucleated and multinucleated myocytes in the human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Stable fetal cardiomyocyte grafts in the hearts of dystrophic mice and dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Bone marrow cells regenerate infarcted myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Changing potency by spontaneous fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.1.49

21 January 2018

Identifiers

DOI

10.1517/14728222.7.1.49

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6 August 2017

1 reference