Therapeutic antibody engineering by high efficiency cell screening (Q35056966)

6 August 2017

title

Therapeutic antibody engineering by high efficiency cell screening (English)

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6 August 2017

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Achim Doerner

1

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6 August 2017

Laura Rhiel

series ordinal

2

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6 August 2017

Stefan Zielonka

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3

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6 August 2017

Harald Kolmar

series ordinal

4

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6 August 2017

language of work or name

English

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publication date

26 November 2013

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6 August 2017

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6 August 2017

volume

588

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6 August 2017

issue

2

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6 August 2017

page(s)

278-287

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Monoclonal antibody therapeutics: history and future

6 August 2017

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Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics

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Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties

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Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

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The future of antibodies as cancer drugs

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Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target

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Selection and rapid purification of murine antibody fragments that bind a transition-state analog by phage display

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Phage display systems and their applications

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Escherichia coli skp chaperone coexpression improves solubility and phage display of single-chain antibody fragments.

21 January 2018

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Enhancement of antibody fragment secretion into the Escherichia coli periplasm by co-expression with the peptidyl prolyl isomerase, FkpA, in the cytoplasm

21 January 2018

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Engineering antibodies for cancer therapy

21 January 2018

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SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies

21 January 2018

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Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.

21 January 2018

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Remodeling domain interfaces to enhance heterodimer formation

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Dual targeting strategies with bispecific antibodies

21 January 2018

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Domain antibodies: proteins for therapy

21 January 2018

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Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: adjusting the bullet to its target

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Cell-based screening using high-throughput flow cytometry

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Imaging flow cytometry: coping with heterogeneity in biological systems

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Cellular image analysis and imaging by flow cytometry

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Protein engineering with bacterial display

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Decorating microbes: surface display of proteins on Escherichia coli

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Ultrahigh-throughput FACS-based screening for directed enzyme evolution

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

E-clonal antibodies: selection of full-length IgG antibodies using bacterial periplasmic display

21 January 2018

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Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli

21 January 2018

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Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening

21 January 2018

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Yeast surface display for screening combinatorial polypeptide libraries

21 January 2018

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Long anchor using Flo1 protein enhances reactivity of cell surface-displayed glucoamylase to polymer substrates

21 January 2018

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Immobilizing proteins on the surface of yeast cells

21 January 2018

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Genetic immobilization of proteins on the yeast cell surface

21 January 2018

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Engineering antibodies by yeast display

21 January 2018

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Yeast surface display for protein engineering and characterization

21 January 2018

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Protein selection using yeast surface display

21 January 2018

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A new yeast display vector permitting free scFv amino termini can augment ligand binding affinities

21 January 2018

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Construction of yeast strains with high cell surface lipase activity by using novel display systems based on the Flo1p flocculation functional domain

21 January 2018

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Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc

21 January 2018

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Directed evolution of proteins for increased stability and expression using yeast display

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Isolating and engineering human antibodies using yeast surface display

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Antibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sources

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Highly stable binding proteins derived from the hyperthermophilic Sso7d scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Affinity maturation of Fab antibody fragments by fluorescent-activated cell sorting of yeast-displayed libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Affinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Pichia surface display: display of proteins on the surface of glycoengineered Pichia pastoris strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

A novel fragment of antigen binding (Fab) surface display platform using glycoengineered Pichia pastoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Isolation of antigen-binding camelid heavy chain antibody fragments (nanobodies) from an immune library displayed on the surface of Pichia pastoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

High-efficiency recovery of target cells using improved yeast display system for detection of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Development of novel whole-cell immunoadsorbents by yeast surface display of the IgG-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Construction of a novel synergistic system for production and recovery of secreted recombinant proteins by the cell surface engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

A dual-mode surface display system for the maturation and production of monoclonal antibodies in glyco-engineered Pichia pastoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Secretion of functional antibody and Fab fragment from yeast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

An improved yeast transformation method for the generation of very large human antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Construction and diversification of yeast cell surface displayed libraries by yeast mating: application to the affinity maturation of Fab antibody fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Yeast mating for combinatorial Fab library generation and surface display

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Mammalian cell display for antibody engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Development of a novel mammalian cell surface antibody display platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Isolation of human monoclonal antibodies by mammalian cell display

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Human anti-EGFL7 recombinant full-length antibodies selected from a mammalian cell-based antibody display library

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

B-cell display-based one-step method to generate chimeric human IgG monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Selecting agonists from single cells infected with combinatorial antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Detection and isolation of auto-reactive human antibodies from primary B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Continuous cultures of fused cells secreting antibody of predefined specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Production of fully human antibodies by transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

The unfolded protein response: from stress pathway to homeostatic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

Bicistronic DNA display for in vitro selection of Fab fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

An integrated approach to extreme thermostabilization and affinity maturation of an antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.025

10.1016/J.FEBSLET.2013.11.025

21 January 2018

Identifiers

DOI

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6 August 2017

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