The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. (Q35062482)

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18 December 2019

review article

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title

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors (English)

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18 December 2019

1

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18 December 2019

Sabine Gerbal-Chaloin

2

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18 December 2019

author name string

L Drocourt

3

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18 December 2019

P Maurel

4

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18 December 2019

M J Vilarem

5

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18 December 2019

language of work or name

English

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publication date

1 February 2003

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Biochimica et Biophysica Acta

18 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

volume

1619

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18 December 2019

issue

3

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18 December 2019

page(s)

243-253

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Cytochrome P450 and the individuality of species

18 December 2019

cites work

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation

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Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

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Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

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Gene induction by Phenobarbital: an update on an old question that receives key novel answers

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Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways

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Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

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A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

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Orphan nuclear receptors: from gene to function

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Molecular mechanisms of action of steroid/thyroid receptor superfamily members

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Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors

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Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors.

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7 January 2021

Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel

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Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes

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Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

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7 January 2021

Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif

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Characterization of DNA-binding proteins required for glucocorticoid induction of CYP3A23.

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Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7.

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Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

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7 January 2021

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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7 January 2021

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7 January 2021

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

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7 January 2021

The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated t

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7 January 2021

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

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7 January 2021

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

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7 January 2021

Enzyme induction in the cytochrome P-450 system

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7 January 2021

Phenobarbital induction of cytochrome P-450 gene expression

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7 January 2021

Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

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7 January 2021

Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes

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7 January 2021

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

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7 January 2021

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

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7 January 2021

Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

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7 January 2021

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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7 January 2021

The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific

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7 January 2021

Gene regulation by vitamin D3.

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A new analog of 1,25-(OH)2D3, 19-NOR-1,25-(OH)2D2, suppresses serum PTH and parathyroid gland growth in uremic rats without elevation of intestinal vitamin D receptor content

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7 January 2021

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Effect of rifampicin and isoniazid on vitamin D metabolism

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Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators

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7 January 2021

Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line

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7 January 2021

Identification of a functional glucocorticoid response element in the CYP3A1/IGC2 gene

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7 January 2021

Circadian variation of the urinary 6beta-hydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity

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7 January 2021

The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness

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7 January 2021

Glucocorticoid regulation of a phenobarbital-inducible cytochrome P-450 gene: the presence of a functional glucocorticoid response element in the 5'-flanking region of the CYP2B2 gene

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7 January 2021

The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes.

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7 January 2021

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

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7 January 2021

The effect of phenobarbital on the transcriptional activity of liver

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7 January 2021

10.1016/S0304-4165(02)00483-X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json

18 December 2019

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