Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors (Q35064987)

6 August 2017

title

Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors (English)

1 reference

6 August 2017

1 reference

A V Vaseva

1

1 reference

6 August 2017

A R Yallowitz

2

1 reference

6 August 2017

N D Marchenko

3

1 reference

6 August 2017

S Xu

4

1 reference

6 August 2017

U M Moll

5

1 reference

6 August 2017

publication date

12 May 2011

1 reference

6 August 2017

published in

Cell Death and Disease

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6 August 2017

volume

2

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6 August 2017

page(s)

e156

1 reference

Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway

6 August 2017

cites work

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A small-molecule inhibitor of MDMX activates p53 and induces apoptosis

8 July 2018

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Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

8 July 2018

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Paradoxical suppression of cellular senescence by p53

8 July 2018

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Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.

8 July 2018

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The p53 orchestra: Mdm2 and Mdmx set the tone

8 July 2018

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Identification and characterization of the first small molecule inhibitor of MDMX

8 July 2018

1 reference

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Drug combination studies and their synergy quantification using the Chou-Talalay method

8 July 2018

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Pharmacological activation of the p53 pathway in haematological malignancies

8 July 2018

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Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma

8 July 2018

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Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells

8 July 2018

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The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells

8 July 2018

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Targeting MDM2 and MDMX in retinoblastoma

8 July 2018

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Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

8 July 2018

1 reference

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Restoration of p53 function leads to tumour regression in vivo

8 July 2018

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Modeling the therapeutic efficacy of p53 restoration in tumors

8 July 2018

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MDM2 inhibitors for cancer therapy

8 July 2018

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Inactivation of the p53 pathway in retinoblastoma.

8 July 2018

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Hdmx modulates the outcome of p53 activation in human tumor cells

8 July 2018

1 reference

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MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

8 July 2018

1 reference

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HSP90 and the chaperoning of cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

8 July 2018

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Hsp90 chaperones wild-type p53 tumor suppressor protein

8 July 2018

1 reference

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8 July 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

Heat shock protein 90 as a molecular target for cancer therapeutics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation.

8 July 2018

1 reference

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Hsp90 inhibitors as selective anticancer drugs.

27 September 2018

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Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122118

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FCDDIS.2011.39

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21562588

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21562588

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21562588

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2011.39

1 reference

Dimensions Publication ID

6 August 2017

0 references

1 reference

6 August 2017

1 reference