Heat shock protein 90 as a molecular target for cancer therapeutics (Q35099516)

6 August 2017

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title

Heat shock protein 90 as a molecular target for cancer therapeutics (English)

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6 August 2017

3

Len Neckers

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6 August 2017

Jennifer S Isaacs

1

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PubMed ID

12676580

6 August 2017

Wanping Xu

series ordinal

2

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6 August 2017

1 March 2003

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6 August 2017

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6 August 2017

3

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6 August 2017

3

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6 August 2017

213-217

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Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Mutations of the VHL tumour suppressor gene in renal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Hypoxia--a key regulatory factor in tumour growth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Stimulation of the weak ATPase activity of human hsp90 by a client protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Hsp90 inhibitors as novel cancer chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

The Hsp90 complex--a super-chaperone machine as a novel drug target

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900029-1

7 January 2021

10.1016/S1535-6108(03)00029-1

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12676580