Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1 (Q35064994)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1 (English)

1 reference

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1 February 2020

author

Apolinar Maya-Mendoza

3

1 reference

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1 February 2020

author name string

A Ahmed

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

J Yang

2

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1 February 2020

D A Jackson

4

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1 February 2020

M Ashcroft

5

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1 February 2020

publication date

19 May 2011

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1 February 2020

published in

Cell Death and Disease

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1 February 2020

volume

2

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1 February 2020

page(s)

e160

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Hypoxia-inducible factors and the response to hypoxic stress

1 February 2020

cites work

1 reference

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Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

8 July 2018

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Chk1 promotes replication fork progression by controlling replication initiation

8 July 2018

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8 July 2018

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MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53

8 July 2018

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Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia

8 July 2018

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Chk1 regulates the density of active replication origins during the vertebrate S phase.

8 July 2018

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HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability

8 July 2018

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H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks

8 July 2018

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Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway

8 July 2018

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gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy.

8 July 2018

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Suppression of replication fork progression in low-dose-specific p53-dependent S-phase DNA damage checkpoint

8 July 2018

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Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

8 July 2018

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Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

8 July 2018

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

8 July 2018

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

8 July 2018

1 reference

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.

8 July 2018

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

Novel cancer therapy by reactivation of the p53 apoptosis pathway.

8 July 2018

1 reference

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A p53-dependent checkpoint pathway prevents rereplication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

8 July 2018

1 reference

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DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells.

8 July 2018

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Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism

8 July 2018

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Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis

8 July 2018

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Regulation of p53 function and stability by phosphorylation

8 July 2018

1 reference

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A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides

8 July 2018

1 reference

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

8 July 2018

1 reference

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

8 July 2018

1 reference

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Activation of a unique p53-dependent DNA damage response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

Visualization of altered replication dynamics after DNA damage in human cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121

Pharmacological rescue of mutant p53 conformation and function

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21593792

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21593792

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2011.42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json

release_mlzsnkg44jgqlm4ifymdp6zuwm

1 February 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/mlzsnkg44jgqlm4ifymdp6zuwm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference