AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes. (Q35080405)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16963559%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

title

AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes (English)

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30 December 2019

6

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30 December 2019

Azucena Salas

7

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30 December 2019

Audrey Ferrand

8

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ORCID Public Data File 2021

author name string

Motomu Shimaoka

1

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30 December 2019

Minsoo Kim

2

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30 December 2019

Edward H Cohen

3

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30 December 2019

Wei Yang

4

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30 December 2019

Nathan Astrof

5

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30 December 2019

Timothy A Springer

9

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30 December 2019

language of work or name

English

0 references

publication date

8 September 2006

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16963559%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

30 December 2019

published in

1 reference

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30 December 2019

volume

103

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30 December 2019

issue

38

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30 December 2019

page(s)

13991-13996

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An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.

30 December 2019

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Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment

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8 July 2018

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

8 July 2018

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Conformational regulation of integrin structure and function

8 July 2018

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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

8 July 2018

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CD18 activation epitopes induced by leukocyte activation

8 July 2018

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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

8 July 2018

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The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils.

8 July 2018

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Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

8 July 2018

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

8 July 2018

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

8 July 2018

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An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

8 July 2018

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Avidity regulation of integrins: the driving force in leukocyte adhesion

8 July 2018

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

8 July 2018

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Structural basis of collagen recognition by integrin alpha2beta1

8 July 2018

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Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.

8 July 2018

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Are changes in integrin affinity and conformation overemphasized?

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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21 January 2018

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Psoriasis as a model for T-cell-mediated disease: immunobiologic and clinical effects of treatment with multiple doses of efalizumab, an anti-CD11a antibody.

21 January 2018

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Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial.

21 January 2018

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Extended efalizumab therapy improves chronic plaque psoriasis: results from a randomized phase III trial.

21 January 2018

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Chemokines and the arrest of lymphocytes rolling under flow conditions.

21 January 2018

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21 January 2018

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Monoclonal antibody IAC-1 is specific for activated alpha2beta1 and binds to amino acids 199 to 201 of the integrin alpha2 I-domain

21 January 2018

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Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b

21 January 2018

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

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Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

21 January 2018

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A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions

27 September 2018

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27 September 2018

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A human lymphocyte-associated antigen involved in cell-mediated lympholysis

16 November 2018

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12 December 2020

Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow

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12 December 2020

A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function.

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12 December 2020

T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0605716103

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16963559%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

0 references

1 reference

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30 December 2019

PubMed publication ID

16963559

1 reference