The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. (Q36322824)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15611342%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2 (English)

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6 January 2020

author

Christopher V. Carman

2

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6 January 2020

Azucena Salas

4

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6 January 2020

author name string

Minsoo Kim

1

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6 January 2020

Wei Yang

3

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6 January 2020

Timothy A Springer

5

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6 January 2020

language of work or name

English

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publication date

1 December 2004

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6 January 2020

published in

Journal of Cell Biology

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6 January 2020

volume

167

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6 January 2020

issue

6

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6 January 2020

page(s)

1241-1253

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

6 January 2020

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Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction

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Avidity modulation activates adhesion under flow and requires cooperativity among adhesion receptors.

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells

30 September 2017

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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

30 September 2017

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Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior

30 September 2017

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30 September 2017

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The microtubule cytoskeleton participates in control of beta2 integrin avidity

30 September 2017

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Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding

30 September 2017

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Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells

30 September 2017

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

30 September 2017

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

30 September 2017

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Avidity regulation of integrins: the driving force in leukocyte adhesion

30 September 2017

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High-resolution FRET microscopy of cholera toxin B-subunit and GPI-anchored proteins in cell plasma membranes

30 September 2017

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Macrophage-enriched myristoylated alanine-rich C kinase substrate and its phosphorylation is required for the phorbol ester-stimulated diffusion of beta 2 integrin molecules

30 September 2017

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The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes

30 September 2017

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Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

30 September 2017

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Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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29 June 2018

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29 June 2018

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29 June 2018

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Divalent cation regulation of the function of the leukocyte integrin LFA-1

29 June 2018

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

29 June 2018

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Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

22 September 2018

1 reference

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Detection of integrin alpha IIbbeta 3 clustering in living cells

22 September 2018

1 reference

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

22 September 2018

1 reference

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Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.

22 September 2018

1 reference

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Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

22 September 2018

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Rapid screening method for inhibitors of protein kinase C

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12 December 2020

T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1

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12 December 2020

The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1

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12 December 2020

Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow

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12 December 2020

Cellular activation of leukocyte function-associated antigen-1 and its affinity are regulated at the I domain allosteric site

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12 December 2020

Identifiers

DOI

10.1083/JCB.200404160

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15611342%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15611342%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PubMed publication ID

15611342

1 reference