Discovering the targets of drugs via computational systems biology (Q35084961)

6 August 2017

2 references

20 June 2019

19 September 2019

Discovering the targets of drugs via computational systems biology (English)

1 reference

biomedical investigative technique

6 August 2017

1 reference

19 September 2019

Frederick P Roth

2

0 references

author name string

Hon Nian Chua

series ordinal

1

1 reference

PubMed ID

21566122

6 August 2017

language of work or name

English

0 references

publication date

12 May 2011

1 reference

PubMed ID

21566122

Journal of Biological Chemistry

6 August 2017

8 July 2011

2 references

20 June 2019

19 September 2019

3 references

6 August 2017

20 June 2019

19 September 2019

286

1 reference

6 August 2017

27

1 reference

6 August 2017

23653-23658

1 reference

Creative Commons Attribution-NonCommercial

6 August 2017

2 references

20 June 2019

19 September 2019

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Predicting drug-target interaction networks based on functional groups and biological features

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Predicting new molecular targets for known drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Predicting drug side-effects by chemical systems biology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

An integrated platform of genomic assays reveals small-molecule bioactivities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Drug target identification using side-effect similarity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

The chemical genomic portrait of yeast: uncovering a phenotype for all genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

STITCH: interaction networks of chemicals and proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Unfinished business: target-based drug discovery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

SuperTarget and Matador: resources for exploring drug-target relationships

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Animal models of human disease: zebrafish swim into view

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Relating protein pharmacology by ligand chemistry

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

The NCI60 human tumour cell line anticancer drug screen

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

The emergence and diffusion of DNA microarray technology

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Global mapping of pharmacological space

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

High-throughput RNAi screening by time-lapse imaging of live human cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

DrugBank: a comprehensive resource for in silico drug discovery and exploration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

High-dimensional and large-scale phenotyping of yeast mutants.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Multi-way clustering of microarray data using probabilistic sparse matrix factorization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Target-based drug discovery: is something wrong?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

A genome-wide overexpression screen in yeast for small-molecule target identification

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

The landscape of genetic complexity across 5,700 gene expression traits in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Can the pharmaceutical industry reduce attrition rates?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Inferring genetic networks and identifying compound mode of action via expression profiling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Systematic genetic analysis with ordered arrays of yeast deletion mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Prediction of protein cellular attributes using pseudo-amino acid composition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Functional discovery via a compendium of expression profiles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Genomic profiling of drug sensitivities via induced haploinsufficiency.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

An information-intensive approach to the molecular pharmacology of cancer.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Identification of common molecular subsequences

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Binding of cycloheximide to ribosomes from wild-type and mutant strains of Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Segmental aneuploidy and the genetic gross structure of the Drosophila genome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Finding function in novel targets: C. elegans as a model organism.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129145

Using Functional Domain Composition and Support Vector Machines for Prediction of Protein Subcellular Location

27 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.174797

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.174797

Human haploinsufficiency — one for sorrow, two for joy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.174797

Genetic basis of individual differences in the response to small-molecule drugs in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.174797

Image-based multivariate profiling of drug responses from single cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21566122

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Drug target validation and identification of secondary drug target effects using DNA microarrays

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21566122

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.R110.174797

1 reference

6 August 2017

1 reference

6 August 2017

1 reference

PubMed ID

21566122