Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101. (Q35086746)

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English	Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101. (English)

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Europe PubMed Central

PubMed publication ID

6 August 2017

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author name string

Yongjun Wang

1

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Europe PubMed Central

PubMed publication ID

6 August 2017

Wei Xiang

2

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6 August 2017

Miao Wang

3

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Europe PubMed Central

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6 August 2017

Tao Huang

4

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6 August 2017

Xingyuan Xiao

5

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Europe PubMed Central

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6 August 2017

Liang Wang

6

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6 August 2017

Dan Tao

7

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Europe PubMed Central

PubMed publication ID

6 August 2017

Liyun Dong

8

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6 August 2017

Fuqing Zeng

9

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6 August 2017

Guosong Jiang

10

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6 August 2017

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publication date

1 February 2014

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6 August 2017

British Journal of Pharmacology

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6 August 2017

171

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PubMed publication ID

6 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

618-635

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Europe PubMed Central

PubMed publication ID

6 August 2017

MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Studies on chemical-structure modification and structure-activity relationship of gambogic acid derivatives at carbon(34).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Studies on chemical structure modification and structure-activity relationship of derivatives of gambogic acid at C(39).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Synthesis and antiangiogenic activity of novel gambogic acid derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Gambogic acid, a natural product inhibitor of Hsp90

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

AN N-terminal Smac peptide sensitizes human prostate carcinoma cells to methyl jasmonate-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Animal research: reporting in vivo experiments: the ARRIVE guidelines

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8 July 2018

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

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8 July 2018

Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Cancer statistics, 2009

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8 July 2018

Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Proteomic identification of molecular targets of gambogic acid: role of stathmin in hepatocellular carcinoma.

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8 July 2018

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

EZH2 promotes proliferation and invasiveness of prostate cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Cooperative cytotoxicity of methyl jasmonate with anti-cancer drugs and 2-deoxy-D-glucose

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

microRNA target predictions in animals

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8 July 2018

Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Control of developmental regulators by Polycomb in human embryonic stem cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Jasmonates in cancer therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

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8 July 2018

Genomic DNA methylation: the mark and its mediators

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8 July 2018

Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder

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8 July 2018

EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

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8 July 2018

A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid

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8 July 2018

Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria

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8 July 2018

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

8 July 2018

Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells

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8 July 2018

Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones

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8 July 2018

Epigenetics in human disease and prospects for epigenetic therapy

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8 July 2018

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay

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8 July 2018

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

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8 July 2018

Worms gang up on bacteria

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8 July 2018

Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells

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8 July 2018

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

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8 July 2018

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

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8 July 2018

Increased EZH2 protein expression is associated with invasive urothelial carcinoma of the bladder

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969076

27 September 2018

Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells.

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27 September 2018

Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1.

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27 September 2018

Enhanced killing of cervical cancer cells by combinations of methyl jasmonate with cisplatin, X or alpha radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24490857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f

1 reference

https://pubmed.ncbi.nlm.nih.gov/24490857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fundamental role of epigenetic events in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24490857

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.12501

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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