The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. (Q35091427)

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English	The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.	scientific article

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31 January 2020

The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model (English)

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31 January 2020

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31 January 2020

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Arun K Sharma

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31 January 2020

Christina L Kline

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31 January 2020

Shantu Amin

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31 January 2020

Rosalyn B Irby

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9 May 2011

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31 January 2020

Clinical Cancer Research

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31 January 2020

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31 January 2020

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31 January 2020

4474-4483

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31 January 2020

Cancer statistics, 2010

1 reference

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8 July 2018

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.

1 reference

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8 July 2018

Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131476

8 July 2018

The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis

1 reference

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Targeting Akt3 signaling in malignant melanoma using isoselenocyanates

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Synthesis and anticancer activity comparison of phenylalkyl isoselenocyanates with corresponding naturally occurring and synthetic isothiocyanates.

1 reference

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8 July 2018

Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis

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8 July 2018

Current overview of the role of Akt in cancer studies via applied immunohistochemistry

1 reference

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8 July 2018

The PI3K/Akt pathway and its downstream transcriptional factors as targets for chemoprevention

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8 July 2018

Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation

1 reference

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8 July 2018

Protein expression and intracellular localization of prostate apoptosis response-4 (Par-4) are associated with apoptosis induction in nasopharyngeal carcinoma cell lines

1 reference

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8 July 2018

Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models

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8 July 2018

Adjuvant therapy of colon cancer: current status and future directions.

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Surgical adjuvant therapy for colorectal cancer: current approaches and future directions

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8 July 2018

The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target

1 reference

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8 July 2018

Binding and phosphorylation of par-4 by akt is essential for cancer cell survival.

1 reference

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8 July 2018

Cancer chemoprevention: scientific promise, clinical uncertainty

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8 July 2018

Phosphorylation of Par-4 by protein kinase A is critical for apoptosis

1 reference

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8 July 2018

Akt: a potential target for thyroid cancer therapy

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The biology and clinical relevance of the PTEN tumor suppressor pathway

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Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism

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8 July 2018

Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression

1 reference

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1 reference

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8 July 2018

Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131476

8 July 2018

The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131476

8 July 2018

Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo

1 reference

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8 July 2018

Expression and function of the leucine zipper protein Par-4 in apoptosis

1 reference

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Serum selenium level in patients with colorectal cancer

1 reference

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Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.

1 reference

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1 reference

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27 September 2018

In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation

1 reference

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AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

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Inactivation of the Candidate Tumor Suppressor Par-4 in Endometrial Cancer

1 reference

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Chemopreventive potential of thiol conjugates of isothiocyanates for lung cancer and a urinary biomarker of dietary isothiocyanates

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555373

12 December 2020

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inferred from PubMed ID database lookup

Chemopreventive agents: selenium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555373

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555373

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Selenium and colorectal adenoma: results of a pooled analysis

1 reference

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inferred from PubMed ID database lookup

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1 reference

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12 December 2020

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inferred from PubMed ID database lookup

The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Prostate apoptosis response gene-4 sensitizes neoplastic lymphocytes to CD95-induced apoptosis

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21555373

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-10-2370

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31 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21555373%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21555373%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

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