Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo (Q35092521)

6 August 2017

Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo (English)

1 reference

6 August 2017

1 reference

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Hiten D. Madhani

14

1 reference

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5 June 2020

Damian J Krysan

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Arielle Butts

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Kristy Koselny

2

1 reference

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5 June 2020

Yeissa Chabrier-Roselló

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Camile P Semighini

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Jessica C S Brown

5

1 reference

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5 June 2020

Xuying Wang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Sivakumar Annadurai

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Louis DiDone

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Julie Tabroff

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Wayne E Childers

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Magid Abou-Gharbia

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Maria E Cardenas

13

1 reference

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5 June 2020

Joseph Heitman

15

1 reference

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5 June 2020

publication date

11 February 2014

1 reference

6 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

5

1 reference

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5 June 2020

page(s)

e00765-13

1 reference

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5 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

Combination antifungal therapy for cryptococcal meningitis

5 June 2020

cites work

1 reference

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Target identification and mechanism of action in chemical biology and drug discovery

8 July 2018

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The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity

8 July 2018

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A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis

8 July 2018

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Drug repurposing in chemical genomics: can we learn from the past to improve the future?

8 July 2018

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Antifungal drug discovery: something old and something new

8 July 2018

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The triple threat of cryptococcosis: it's the body site, the strain, and/or the host

8 July 2018

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Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review.

8 July 2018

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Thermal denaturation assays in chemical biology

8 July 2018

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Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics

8 July 2018

1 reference

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Dynamics of Cryptococcus neoformans-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in humans

8 July 2018

1 reference

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Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

8 July 2018

1 reference

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ScreenMill: a freely available software suite for growth measurement, analysis and visualization of high-throughput screen data

8 July 2018

1 reference

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Cryptococcal interactions with the host immune system.

8 July 2018

1 reference

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Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.

8 July 2018

1 reference

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Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients

8 July 2018

1 reference

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Treatment of cryptococcal meningitis in resource limited settings

8 July 2018

1 reference

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Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization

8 July 2018

1 reference

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Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

8 July 2018

1 reference

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Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans

8 July 2018

1 reference

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Small molecule regulators of autophagy identified by an image-based high-throughput screen

8 July 2018

1 reference

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A strategy for extracting and analyzing large-scale quantitative epistatic interaction data

8 July 2018

1 reference

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Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth

8 July 2018

1 reference

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Combination treatment of invasive fungal infections

8 July 2018

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Selective optimization of side activities: another way for drug discovery

8 July 2018

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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

8 July 2018

1 reference

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Pharmacokinetics of selective estrogen receptor modulators

8 July 2018

1 reference

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

8 July 2018

1 reference

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Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling

8 July 2018

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Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae

8 July 2018

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Conditional lethality of the diprotic weak bases chloroquine and quinacrine against Cryptococcus neoformans

8 July 2018

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Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans

8 July 2018

1 reference

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Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion.

8 July 2018

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High-dose toremifene as a cisplatin modulator in metastatic non-small cell lung cancer: targeted plasma levels are achievable clinically

8 July 2018

1 reference

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Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast

8 July 2018

1 reference

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Observation and significance of growth inhibition of Saccharomyces cerevisiae (A224A) by the anti-oestrogen drug tamoxifen

8 July 2018

1 reference

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Ca2(+)-dependent binding of tamoxifen to calmodulin isolated from bovine brain.

8 July 2018

1 reference

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Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients

8 July 2018

1 reference

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Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes.

8 July 2018

1 reference

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Multicenter phase II feasibility trial of high-dose tamoxifen in patients with refractory or relapsed multiple myeloma

27 September 2018

1 reference

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Antifungal Activity of Amiodarone Is Mediated by Disruption of Calcium Homeostasis

27 September 2018

1 reference

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Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

27 September 2018

1 reference

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Synergic inhibitory activity of amphotericin-B and γ interferon against intracellular Cryptococcus neoformans in murine macrophages

25 October 2018

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12 December 2020

[Antitumor activity of a new antiestrogenic drug, toremifene (NK622) against human breast cancer xenografts in nude mice]

1 reference

12 December 2020

Homologs of idoxifene: variation of estrogen receptor binding and calmodulin antagonism with chain length

1 reference

12 December 2020

Binding of centrins and yeast calmodulin to synthetic peptides corresponding to binding sites in the spindle pole body components Kar1p and Spc110p

1 reference

12 December 2020

1 reference

12 December 2020

P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration

1 reference

12 December 2020

Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues

1 reference

12 December 2020

Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells

1 reference

12 December 2020

Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient

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12 December 2020

Identifiers

DOI

10.1128/MBIO.00765-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520056%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference