Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases (Q35099028)

6 August 2017

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title

Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases (English)

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6 August 2017

cardiovascular disease

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Jingjing Liu

1

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6 August 2017

Yitao Wang

2

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6 August 2017

Lan Qiu

3

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6 August 2017

Yuanyuan Yu

4

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6 August 2017

Chunming Wang

5

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6 August 2017

language of work or name

English

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publication date

21 February 2014

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Expert Opinion on Investigational Drugs

6 August 2017

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6 August 2017

23

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6 August 2017

523-539

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6 August 2017

4

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Pharmacological activity of sanchi ginseng (Panax notoginseng).

6 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Bioactive saponins and glycosides. XIX. Notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of notoginsenosides-L, -M, and -N from the roots of Panax notoginseng (Burk.) F. H. Chen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Two new dammarane triterpene glycosides from the rhizomes of Panax notoginseng

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Dammarane-type glycosides from steamed notoginseng

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

A rapid ultra-performance liquid chromatography-electrospray Ionisation mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Target separation of a new anti-tumor saponin and metabolic profiling of leaves of Panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Chemical investigation of saponins in different parts of Panax notoginseng by pressurized liquid extraction and liquid chromatography-electrospray ionization-tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Total panax notoginsenosides prevent atherosclerosis in apolipoprotein E-knockout mice: Role of downregulation of CD40 and MMP-9 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Panax notogingseng saponins suppress RAGE/MAPK signaling and NF-kappaB activation in apolipoprotein-E-deficient atherosclerosis-prone mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Proteomic analysis of differential protein expression in rat platelets treated with notoginsengnosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Comparative study on saponin fractions from Panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Inflammation in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

From endothelial dysfunction to atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

The immune system in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Macrophages in the pathogenesis of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Panax notoginseng saponins attenuate atherosclerosis via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

A novel LXR-alpha activator identified from the natural product Gynostemma pentaphyllum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Ginsenoside-Rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoE knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Integrin-regulated FAK-Src signaling in normal and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Panax notoginseng saponins inhibit Zymosan A induced atherosclerosis by suppressing integrin expression, FAK activation and NF-κB translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Mechanism of altered TNF-alpha expression by macrophage and the modulatory effect of Panax notoginseng saponins in scald mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-kappaB signaling pathway in murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Panax notoginseng saponins attenuate atherogenesis accelerated by zymosan in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Activation of liver X receptor reduces global ischemic brain injury by reduction of nuclear factor-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Liver x receptors in atherosclerosis and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Inhibitory effect of trilinolein on angiotensin II-induced cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Fibronectin promotes cell cycle entry in smooth muscle cells in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Ginsenoside-Rd, a new voltage-independent Ca2+ entry blocker, reverses basilar hypertrophic remodeling in stroke-prone renovascular hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Ginsenoside-Rd potentiates apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through the mitochondrial pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Ginsenoside Rb₁ inhibits the carotid neointimal hyperplasia induced by balloon injury in rats via suppressing the phenotype modulation of vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Antioxidant effects of ginsenoside Re in cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Association of the metabolic syndrome with history of myocardial infarction and stroke in the Third National Health and Nutrition Examination Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Association between change in plasma triglyceride levels and risk of stroke and carotid atherosclerosis: systematic review and meta-regression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

LDL oxidative modification and carotid atherosclerosis: Results of a multicenter study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Lipid-lowering therapies in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Liver X receptor in cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Antiatherosclerotic effect of farnesoid X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Comparison of plasminogen activator inhibitor-1, tissue type plasminogen activator antigen, fibrinogen, and D-dimer levels in various age decades in patients with type 2 diabetes mellitus and stable coronary artery disease (from the BARI 2D trial).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Notoginsenoside R1 from Panax notoginseng inhibits TNF-alpha-induced PAI-1 production in human aortic smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Panax notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Atherosclerosis: current pathogenesis and therapeutic options

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Platelets, atherosclerosis and the endothelium: new therapeutic targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Role of nitric oxide in ginsenoside Rg(1)-induced protection against left ventricular hypertrophy produced by abdominal aorta coarctation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Comparative studies of saponins in 1-3-year-old main roots, fibrous roots, and rhizomes of Panax notoginseng, and identification of different parts and growth-year samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Biological networks and analysis of experimental data in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Systems biology impact on antiepileptic drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

The influence of Sam-Chil-Geun (Panax notoginseng) on the serum lipid levels and inflammations of rats with hyperlipidemia induced by poloxamer-407.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Pharmacokinetic and absolute bioavailability study of total panax notoginsenoside, a typical multiple constituent traditional chinese medicine (TCM) in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Self-micelle formation and the incorporation of lipid in the formulation affect the intestinal absorption of Panax notoginseng

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Toll-like receptor ligand-induced activation of murine DC2.4 cells is attenuated by Panax notoginseng

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.892582

Hydrolytic Reaction of Plant Extracts to Generate Molecular Diversity: New Dammarane Glycosides from the Mild Acid Hydrolysate of Root Saponins ofPanax notoginseng

21 January 2018

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/HLCA.200490116

Two New Dammarane-Type Bisdesmosides from the Fruit Pedicels ofPanax notoginseng

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/HLCA.200890013

5,6-Didehydroginsenosides from the roots of Panax notoginseng

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.3390/MOLECULES15118169

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1248/CPB.45.1056

Bioactive saponins and glycosides. VIII. Notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Burk.) F.H. Chen

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1248/CPB.45.1039

Identifiers

DOI

10.1517/13543784.2014.892582

1 reference

6 August 2017

1 reference