Atherosclerosis: current pathogenesis and therapeutic options (Q37953777)

25 August 2017

Atherosclerosis: current pathogenesis and therapeutic options (English)

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25 August 2017

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25 August 2017

Heidi Noels

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PubMed ID

22064431

25 August 2017

language of work or name

English

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publication date

7 November 2011

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25 August 2017

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25 August 2017

17

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25 August 2017

1410-1422

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25 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nm.2538

25 August 2017

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cites work

Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice

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12 December 2020

The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes

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12 December 2020

Elimination of platelet factor 4 (PF4) from platelets reduces atherosclerosis in C57Bl/6 and apoE-/- mice

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12 December 2020

Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice

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12 December 2020

Platelets as immune cells: bridging inflammation and cardiovascular disease

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12 December 2020

Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils

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12 December 2020

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

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12 December 2020

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent

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12 December 2020

Macrophage death and defective inflammation resolution in atherosclerosis

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12 December 2020

Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial

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12 December 2020

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

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12 December 2020

A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice

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12 December 2020

GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions

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12 December 2020

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.

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12 December 2020

Lp-PLA₂- a novel risk factor for high-risk coronary and carotid artery disease

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12 December 2020

Structure and function of HDL mimetics

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12 December 2020

Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis

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12 December 2020

The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges

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12 December 2020

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

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12 December 2020

Macrophage migration inhibitory factor: a noncanonical chemokine important in atherosclerosis

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12 December 2020

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

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12 December 2020

Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice.

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12 December 2020

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

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12 December 2020

Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions

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12 December 2020

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

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12 December 2020

Vessel wall-embedded dendritic cells induce T-cell autoreactivity and initiate vascular inflammation.

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12 December 2020

MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism

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12 December 2020

Effect of intensive lipid lowering on progression of coronary atherosclerosis: evidence for an early benefit from the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial

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12 December 2020

Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis.

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12 December 2020

Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies

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12 December 2020

Monocytes in atherosclerosis: subsets and functions

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12 December 2020

CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient mice

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12 December 2020

A New Monocyte Chemotactic Protein-1/Chemokine CC Motif Ligand-2 Competitor Limiting Neointima Formation and Myocardial Ischemia/Reperfusion Injury in Mice

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12 December 2020

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

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12 December 2020

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

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12 December 2020

ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation

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12 December 2020

Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model

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12 December 2020

Dendritic cells pulsed with malondialdehyde modified low density lipoprotein aggravate atherosclerosis in Apoe(-/-) mice

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12 December 2020

Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium

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12 December 2020

Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium

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12 December 2020

Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis.

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12 December 2020

Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality

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12 December 2020

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

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12 December 2020

Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha

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12 December 2020

Immunomodulation of atherosclerosis: implications for vaccine development

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12 December 2020

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

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12 December 2020

Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection

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12 December 2020

Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice.

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12 December 2020

Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase

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12 December 2020

Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress

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12 December 2020

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

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12 December 2020

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

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12 December 2020

Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis

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12 December 2020

Role of Bone Marrow–Derived CC-Chemokine Receptor 5 in the Development of Atherosclerosis of Low-Density Lipoprotein Receptor Knockout Mice

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12 December 2020

Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis

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12 December 2020

Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosc

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12 December 2020

Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice.

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12 December 2020

Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region

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12 December 2020

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

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12 December 2020

Biological, clinical and population relevance of 95 loci for blood lipids

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12 December 2020

Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial

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12 December 2020

Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis.

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12 December 2020

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

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12 December 2020

Emerging role of Toll-like receptors in atherosclerosis

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12 December 2020

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

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12 December 2020

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

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12 December 2020

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

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12 December 2020

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

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12 December 2020

The immune system in atherosclerosis

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12 December 2020

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

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12 December 2020

Extended-release niacin or ezetimibe and carotid intima-media thickness.

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12 December 2020

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

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12 December 2020

Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events

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12 December 2020

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

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12 December 2020

Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization

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12 December 2020

Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects

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12 December 2020

Ticagrelor versus clopidogrel in patients with acute coronary syndromes

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12 December 2020

Genetics of myocardial infarction: a progress report

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12 December 2020

Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions

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12 December 2020

Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice

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12 December 2020

Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials

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12 December 2020

Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque

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12 December 2020

Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

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12 December 2020

The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

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12 December 2020

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves

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12 December 2020

T-cell costimulation and coinhibition in atherosclerosis.

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12 December 2020

Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis

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12 December 2020

B cell depletion reduces the development of atherosclerosis in mice

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12 December 2020

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

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12 December 2020

Chemokine receptor 7 knockout attenuates atherosclerotic plaque development

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12 December 2020

Beta-blockers and progression of coronary atherosclerosis: pooled analysis of 4 intravascular ultrasonography trials.

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12 December 2020

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

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12 December 2020

Contribution of macromolecular structure to the retention of low-density lipoprotein at arterial branch points

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12 December 2020

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression

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12 December 2020

The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels

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12 December 2020

CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden

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12 December 2020

Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial

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12 December 2020

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

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12 December 2020

Telmisartan, ramipril, or both in patients at high risk for vascular events

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12 December 2020

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

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12 December 2020

Phagocyte partnership during the onset and resolution of inflammation.

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12 December 2020

Synergistic proinflammatory effects of the antiviral cytokine interferon-alpha and Toll-like receptor 4 ligands in the atherosclerotic plaque

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12 December 2020

Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo

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12 December 2020

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.

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12 December 2020

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

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12 December 2020

Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium

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12 December 2020

Direct antiatherosclerotic effects of PPAR agonists

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12 December 2020

Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia

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12 December 2020

T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses

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12 December 2020

Circulating microRNAs in patients with coronary artery disease.

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12 December 2020

Therapeutic targeting of chemokine interactions in atherosclerosis

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12 December 2020

Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice

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12 December 2020

Macrophages in the pathogenesis of atherosclerosis

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12 December 2020

Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials

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12 December 2020

NETs: a new strategy for using old weapons

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12 December 2020

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

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12 December 2020

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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12 December 2020

Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1(-/-)/low-density lipoprotein receptor(-/-) mice

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12 December 2020

Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial

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12 December 2020

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice

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12 December 2020

Chemokines in the vascular inflammatory response of atherosclerosis

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12 December 2020

Network of vascular-associated dendritic cells in intima of healthy young individuals

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12 December 2020

The multi-functionality of CD40L and its receptor CD40 in atherosclerosis.

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12 December 2020

Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions.

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12 December 2020

Unexpected protective role for Toll-like receptor 3 in the arterial wall

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12 December 2020

Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis

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12 December 2020

Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells

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12 December 2020

Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice

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12 December 2020

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

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12 December 2020

Stabilisation of atherosclerotic plaques

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12 December 2020

Endoplasmic reticulum stress and atherosclerosis

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12 December 2020

High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice.

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12 December 2020

Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

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12 December 2020

Neutrophil secretion products pave the way for inflammatory monocytes

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12 December 2020

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

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12 December 2020

Identifiers

DOI

10.1038/NM.2538

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25 August 2017

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PubMed ID

22064431