The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure (Q35103993)

6 August 2017

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title

The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure (English)

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6 August 2017

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Bart O Roep

1

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6 August 2017

22 March 2003

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6 August 2017

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6 August 2017

46

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6 August 2017

3

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6 August 2017

305-321

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https://scigraph.springernature.com/pub.10.1007/s00125-003-1089-5

6 August 2017

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cites work

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21 January 2018

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21 January 2018

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Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.

21 January 2018

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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

21 January 2018

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

21 January 2018

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21 January 2018

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GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.

21 January 2018

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Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.

21 January 2018

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Increased expression of T-cell markers of immunological memory associated with protection from type I diabetes. A study of identical twins.

21 January 2018

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Immunological studies on type 1 diabetes in identical twins

21 January 2018

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Early T-cell defects in pre-type 1 diabetes

21 January 2018

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Autoreactive and immunoregulatory T-cell subsets in insulin-dependent diabetes mellitus.

21 January 2018

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Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays

21 January 2018

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Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes

21 January 2018

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Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

21 January 2018

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

21 January 2018

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Inhibition of human CD4(+)CD25(+high) regulatory T cell function

21 January 2018

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The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells

21 January 2018

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Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop fo

21 January 2018

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T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient

21 January 2018

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Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient

21 January 2018

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Modulation of autoimmunity to beta-cell antigens by proteases

21 January 2018

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Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.

21 January 2018

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Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study

21 January 2018

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Seasonality of birth in patients with type 1 diabetes

21 January 2018

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Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians

21 January 2018

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Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).

21 January 2018

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T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele

21 January 2018

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Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes

21 January 2018

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T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase

21 January 2018

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Antigen arrays in T cell immunology

21 January 2018

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ASSOCIATION OF CYTOMEGALOVIRUS INFECTION WITH AUTOIMMUNE TYPE 1 DIABETES

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody

21 January 2018

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Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

21 January 2018

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Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

21 January 2018

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The NOD mouse model of type 1 diabetes: as good as it gets?

21 January 2018

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Isohormonal therapy of endocrine autoimmunity.

21 January 2018

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Insulin prophylaxis in individuals at high risk of type I diabetes

21 January 2018

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Effects of insulin in relatives of patients with type 1 diabetes mellitus

21 January 2018

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Autoantibody response to islet transplantation in type 1 diabetes

21 January 2018

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Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

21 January 2018

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Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: its relevance for treatment in established diabetes and islet transplantation

21 January 2018

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T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes

21 January 2018

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Autoimmune diabetes: the role of T cells, MHC molecules and autoantigens.

21 January 2018

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Molecular basis and functional importance of some disease-associated HLA polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

T Cell Proliferative Responses to Glutamic Acid Decarboxylase-65 in IDDM are Negatively Associated with HLA DR3/4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

HLA-matched control subjects are essential in studies of susceptibility to IDDM

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-003-1089-5

Occult CD45 T cell developmental defect in type 1 diabetes.

21 January 2018

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12 December 2020

Proposed guidelines on screening for risk of type 1 diabetes

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12 December 2020

CD4+CD25high regulatory cells in human peripheral blood

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12 December 2020

Molecular mimicry and immune-mediated diseases

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12 December 2020

Can we change the course of beta-cell destruction in type 1 diabetes?

1 reference

12 December 2020

Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells

1 reference

12 December 2020

The relationship between humoral and cellular immunity to IA-2 in IDDM

1 reference

12 December 2020

Pathologic anatomy of the pancreas in juvenile diabetes mellitus

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12 December 2020

Dependence of Antigen Expression on Functional State of -Cells

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12 December 2020

CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.

1 reference

12 December 2020

Effects of immunosuppression with cyclosporine on beta cell function and clinical remission in very early overt type I diabetes

1 reference

12 December 2020

Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus

1 reference

12 December 2020

Th1-like cytokine production profile and individual specific alterations in TCRBV-gene usage of T cells from newly diagnosed type 1 diabetes patients after stimulation with beta-cell antigens

1 reference

12 December 2020

Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases

1 reference

12 December 2020

Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes

1 reference

12 December 2020

T helper cell subsets in insulin-dependent diabetes

1 reference

12 December 2020

Co-expression of CD45RA (naive) and CD45RO (memory) T-cell markers

1 reference

12 December 2020

Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins

1 reference

12 December 2020

Persistent reduction of CD4/CD8 lymphocyte ratio and cell activation before the onset of type 1 (insulin-dependent) diabetes

1 reference

12 December 2020

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile

1 reference

12 December 2020

HLA class II associations with Type 1 diabetes mellitus: a multivariate approach

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12 December 2020

Acute Onset of Type I Diabetes Mellitus after Severe Echovirus 9 Infection: Putative Pathogenic Pathways

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12 December 2020

Autoimmune versus inflammatory type I diabetes: a controversy?

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12 December 2020

Development of type 1 diabetes despite severe hereditary B-cell deficiency

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12 December 2020

Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes

1 reference

12 December 2020

Characterization of T Lymphocytes Infiltrating Human Pancreas Allograft Affected by Isletitis and Recurrent Diabetes

1 reference

12 December 2020

Standardization of T-cell assays in Type I diabetes. Immunology of Diabetes Society T-cell Committee

1 reference

12 December 2020

T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes

1 reference

12 December 2020

T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides

1 reference

12 December 2020

Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart

1 reference

12 December 2020

T-cell markers in type I diabetes: progress, prospects and realistic expectations

1 reference

12 December 2020

Increased Numbers ofin vivoActivated T cells in Patients with Recent Onset Insulin-dependent Diabetes Mellitus

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12 December 2020

Closing in on type 1 diabetes

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12 December 2020

Examination of islets in the pancreas biopsy specimens from newly diagnosed Type 1 (insulin-dependent) diabetic patients

1 reference

12 December 2020

GAD65-Reactive T cells in a non-diabetic stiff-man syndrome patient

1 reference

12 December 2020

Lack of predictive value of islet cell antibodies, insulin antibodies, and HLA-DR phenotype for remission in cyclosporin-treated IDDM patients. The Canadian-European Randomized Control Trial Group

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12 December 2020

Plasmapheresis in the initial treatment of insulin-dependent diabetes mellitus in children.

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12 December 2020

Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group

1 reference

12 December 2020

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1 reference

12 December 2020

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases

1 reference

12 December 2020

T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM

1 reference

12 December 2020

Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin

1 reference

12 December 2020

Abnormal T-lymphocyte subsets in type I diabetes

1 reference

12 December 2020

High T cell responses to the glutamic acid decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes

1 reference

12 December 2020

Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry

1 reference

12 December 2020

PHASE I STUDY OF AN ENGINEERED AGLYCOSYLATED HUMANIZED CD3 ANTIBODY IN RENAL TRANSPLANT REJECTION1

1 reference

12 December 2020

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice

1 reference

12 December 2020

HLA-DR binding analysis of peptides from islet antigens in IDDM

1 reference

12 December 2020

HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus

1 reference

12 December 2020

Defective maturation and function of antigen-presenting cells in type 1 diabetes

1 reference

12 December 2020

Tolerance to kidney allograft transplanted into Type I diabetic patients persists after in vivo challenge with pancreatic islet allografts that express repeated mismatches

1 reference

12 December 2020

Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2)

1 reference

12 December 2020

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1 reference

12 December 2020

Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries

1 reference

12 December 2020

Inhibition of insulin-specific autoreactive T-cells by sulphatide which is variably expressed in beta cells

1 reference

12 December 2020

Circulating forms of ICAM-3 (cICAM-3). Elevated levels in autoimmune diseases and lack of association with cICAM-1.

1 reference

12 December 2020

Lymphocyte subset abnormalities, autoantibodies and their relationship with HLA DR types in children with type 1 (insulin-dependent) diabetes and their first degree relatives

1 reference

12 December 2020

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1 reference

12 December 2020

In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis

1 reference

12 December 2020

Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus

1 reference

12 December 2020

Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects

1 reference

12 December 2020

Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation

1 reference

12 December 2020

10.1007/S00125-003-1089-5

Identifiers

DOI

0 references

PubMed ID

12687328

1 reference

PubMed ID

12687328