Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. (Q35105102)

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5 February 2020

title

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration (English)

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1

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Sina Farsiu

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author name string

Lincoln V Johnson

2

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Rolf Herrmann

3

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Stephanie G Smith

5

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Marybeth Groelle

6

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Brian E Mace

7

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Patrick Sullivan

8

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Jeffrey A Jamison

9

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Una Kelly

10

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Ons Harrabi

11

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Sangeetha Subbarao Bollini

12

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Jeanette Dilley

13

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Dione Kobayashi

14

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Bing Kuang

15

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Wenlin Li

16

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Jaume Pons

17

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John C Lin

18

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Catherine Bowes Rickman

19

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language of work or name

English

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publication date

20 June 2011

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Proceedings of the National Academy of Sciences of the United States of America

5 February 2020

published in

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volume

108

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issue

28

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5 February 2020

page(s)

E279-87

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Can novel therapeutics halt the amyloid cascade?

5 February 2020

cites work

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Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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27 September 2018

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Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells

27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD)

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Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells

21 January 2018

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Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice

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The retinal pigment epithelium. II. Histologic changes associated with age

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Age-related macular degeneration

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A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy

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Dietary fat and age-related maculopathy

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Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

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Clusterin is present in drusen in age-related macular degeneration

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Identifiers

DOI

10.1073/PNAS.1100901108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690377%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690377%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference