Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins (Q35105442)

6 August 2017

Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins (English)

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6 August 2017

Shinji Kamisuki

1

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6 August 2017

Takashi Shirakawa

2

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6 August 2017

Akira Kugimiya

3

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6 August 2017

Lutfi Abu-Elheiga

4

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6 August 2017

Hea-Young Park Choo

5

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6 August 2017

Kohei Yamada

6

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6 August 2017

Hiroki Shimogawa

7

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6 August 2017

Salih J Wakil

8

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6 August 2017

Motonari Uesugi

9

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6 August 2017

language of work or name

English

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publication date

8 June 2011

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Journal of Medicinal Chemistry

6 August 2017

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6 August 2017

54

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6 August 2017

13

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6 August 2017

4923-4927

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A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Protein sensors for membrane sterols

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Identification of bioactive molecules by adipogenesis profiling of organic compounds

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136361

27 September 2018

Identifiers

DOI

10.1021/JM200304Y

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6 August 2017

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6 August 2017

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