Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function. (Q35107102)

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8 February 2020

title

Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function (English)

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8 February 2020

3

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8 February 2020

Michael J. Rogers

5

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8 February 2020

author name string

Adam Taylor

1

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8 February 2020

Emilie H Mules

2

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8 February 2020

Miep H Helfrich

4

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8 February 2020

Fraser P Coxon

6

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8 February 2020

publication date

1 May 2011

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8 February 2020

published in

Small GTPases (journal)

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8 February 2020

volume

2

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8 February 2020

issue

3

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8 February 2020

page(s)

131-142

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describes a project that uses

8 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3136943/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells

9 July 2018

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Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.

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Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients

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Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption

9 July 2018

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Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2

9 July 2018

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Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases

9 July 2018

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Intracellular membrane trafficking in bone resorbing osteoclasts

9 July 2018

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Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

9 July 2018

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Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption

9 July 2018

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Rab27a regulates the peripheral distribution of melanosomes in melanocytes

9 July 2018

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Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

9 July 2018

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9 July 2018

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Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

9 July 2018

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9 July 2018

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Inherited abnormalities in platelet organelles and platelet formation and associated altered expression of low molecular weight guanosine triphosphate-binding proteins in the mouse pigment mutant gunmetal.

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

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27 September 2018

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Crossref

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Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand

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12 December 2020

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12 December 2020

Osteoclast formation and bone resorption are inhibited by megakaryocytes

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12 December 2020

Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake

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12 December 2020

Expression of osteoprotegerin mRNA and protein in murine megakaryocytes

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12 December 2020

Identifiers

DOI

10.4161/SGTP.2.3.16488

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21776414%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21776414%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference