Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential. (Q35107172)

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9 March 2020

title

Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential (English)

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9 March 2020

2

Campbell R Sheen

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Kellen Cristina da Silva Gasque

9 March 2020

3

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9 March 2020

Maytê Bolean

4

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9 March 2020

Pietro Ciancaglini

5

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9 March 2020

author name string

Tina Kiffer-Moreira

1

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9 March 2020

Andrea van Elsas

6

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9 March 2020

Marc F Hoylaerts

7

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9 March 2020

José Luis Millán

8

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9 March 2020

language of work or name

English

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publication date

24 February 2014

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9 March 2020

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9 March 2020

volume

9

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9 March 2020

page(s)

e89374

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issue

2

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Creative Commons Attribution 4.0 International

9 March 2020

copyright license

start time

24 February 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Alkaline phosphatases contribute to uterine receptivity, implantation, decidualization, and defense against bacterial endotoxin in hamsters

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Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine

9 July 2018

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Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.

9 July 2018

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Intestinal alkaline phosphatase prevents metabolic syndrome in mice

9 July 2018

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Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate

9 July 2018

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Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury

9 July 2018

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Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial

9 July 2018

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Dose response of bone-targeted enzyme replacement for murine hypophosphatasia

9 July 2018

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Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia

9 July 2018

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A role for intestinal alkaline phosphatase in the maintenance of local gut immunity

9 July 2018

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Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site

9 July 2018

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Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis

9 July 2018

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Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles

9 July 2018

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The SWISS-MODEL Repository and associated resources

9 July 2018

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Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition

9 July 2018

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Enzyme replacement therapy for murine hypophosphatasia

9 July 2018

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Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota

9 July 2018

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Structural studies of human placental alkaline phosphatase in complex with functional ligands.

9 July 2018

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Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone

9 July 2018

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9 July 2018

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Accelerated Fat Absorption in Intestinal Alkaline Phosphatase Knockout Mice

9 July 2018

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Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide

9 July 2018

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Structural evidence of functional divergence in human alkaline phosphatases

9 July 2018

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Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

9 July 2018

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Function assignment to conserved residues in mammalian alkaline phosphatases

9 July 2018

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Differentiation of the slow-binding mechanism for magnesium ion activation and zinc ion inhibition of human placental alkaline phosphatase

9 July 2018

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Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization

9 July 2018

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Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity

9 July 2018

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

9 July 2018

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Modifications in a flexible surface loop modulate the isozyme-specific properties of mammalian alkaline phosphatases

9 July 2018

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Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.

9 July 2018

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Site-directed mutagenesis and epitope-mapped monoclonal antibodies define a catalytically important conformational difference between human placental and germ cell alkaline phosphatase

9 July 2018

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Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Enzyme-replacement therapy in life-threatening hypophosphatasia.

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Adenine monolayers on the Au(111) surface: structure identification by scanning tunneling microscopy experiment and ab initio calculations

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Genetic complexity, structure, and characterization of highly active bovine intestinal alkaline phosphatases.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933536

Mammalian Alkaline Phosphatases

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0089374

Can biological calcification occur in the presence of pyrophosphate?

21 January 2018

1 reference

12 December 2020

Segment-specific localization of intestinal-type alkaline phosphatase in human kidney

1 reference

12 December 2020

Dependence of divalent metal ions on phosphotransferase activity of osseous plate alkaline phosphatase

1 reference

12 December 2020

Mammalian alkaline phosphatases are allosteric enzymes

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12 December 2020

A novel phosphatase upregulated in Akp3 knockout mice

1 reference

12 December 2020

Role of metal ions on the secondary and quaternary structure of alkaline phosphatase from bovine intestinal mucosa

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0089374

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