Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo (Q35120026)

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scholarly article

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English	Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo	scholarly article

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scholarly article

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21 December 2019

Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo (English)

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21 December 2019

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Jeremy A. Squire

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21 December 2019

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21 December 2019

author name string

J A Kennedy

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21 December 2019

F Barabé

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21 December 2019

B J Patterson

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21 December 2019

J Bayani

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21 December 2019

D L Barber

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21 December 2019

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31 October 2006

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21 December 2019

Proceedings of the National Academy of Sciences of the United States of America

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21 December 2019

103

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21 December 2019

45

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21 December 2019

16930-16935

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21 December 2019

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

1 reference

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9 July 2018

Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

1 reference

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9 July 2018

Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation

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Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells

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9 July 2018

PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation

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A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia

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9 July 2018

A gain-of-function mutation of JAK2 in myeloproliferative disorders

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9 July 2018

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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9 July 2018

The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2

1 reference

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9 July 2018

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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9 July 2018

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

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9 July 2018

The Janus kinases (Jaks)

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9 July 2018

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation

1 reference

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9 July 2018

TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways

1 reference

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9 July 2018

TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway

1 reference

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9 July 2018

Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo

1 reference

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9 July 2018

Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells

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9 July 2018

Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling

1 reference

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9 July 2018

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1 reference

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9 July 2018

Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells

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9 July 2018

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

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9 July 2018

Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia

1 reference

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9 July 2018

Letter: Bone-marrow responses in polycythemia vera.

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9 July 2018

The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene

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21 January 2018

Myelodysplastic/myeloproliferative disease with erythropoietic hyperplasia (erythroid preleukemia) and the unique translocation (8;9)(p23;p24): first description of a case

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Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells

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Distinct classes of human stem cells that differ in proliferative and self-renewal potential

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Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols.

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21 January 2018

Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera.

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21 January 2018

Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programming

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21 January 2018

Myeloproliferative disorders carrying the t(8;9) (PCM1-JAK2) translocation.

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21 January 2018

AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation

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BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice

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21 January 2018

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

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Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice

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12 December 2020

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Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice

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Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells

1 reference

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12 December 2020

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A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma

1 reference

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12 December 2020

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Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells

1 reference

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12 December 2020

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Identifiers

10.1073/PNAS.0604902103

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21 December 2019

2006PNAS..10316930K

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21 December 2019

1 reference

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21 December 2019

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