Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice (Q75312804)

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17 November 2019

review article

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title

Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737125%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

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Annapoorni Rangarajan

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737125%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Robert A Weinberg

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737125%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

publication date

1 December 2003

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17 November 2019

published in

Nature Reviews Cancer

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17 November 2019

volume

3

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17 November 2019

page(s)

952-959

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17 November 2019

issue

12

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https://scigraph.springernature.com/pub.10.1038/nrc1235

17 November 2019

exact match

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cites work

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

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Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells

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Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Increasing complexity of Ras signaling.

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Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

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Creation of human tumour cells with defined genetic elements

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

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CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

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Transformation of normal human cells in the absence of telomerase activation.

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Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells

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Distinct requirements for Ras oncogenesis in human versus mouse cells

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p107 is a suppressor of retinoblastoma development in pRb-deficient mice

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Essential role for oncogenic Ras in tumour maintenance

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Neurofibromas in NF1: Schwann cell origin and role of tumor environment

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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

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Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization

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Age distribution of cancer in mice: the incidence turnover at old age

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Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

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Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

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31 March 2020

Identifiers

DOI

10.1038/NRC1235

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737125%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 November 2019

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