PCSK9 is a critical regulator of the innate immune response and septic shock outcome. (Q35125516)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320235%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

PCSK9 is a critical regulator of the innate immune response and septic shock outcome (English)

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21 February 2020

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21 February 2020

Jason D. Christie

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21 February 2020

Christopher Fjell

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Nuala J Meyer

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21 February 2020

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Keith R Walley

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21 February 2020

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Mihai S Cirstea

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21 February 2020

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John H Boyd

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21 February 2020

author name string

Katherine R Thain

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21 February 2020

James A Russell

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21 February 2020

Jane F Ferguson

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21 February 2020

Taka-aki Nakada

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21 February 2020

Simone A Thair

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21 February 2020

language of work or name

English

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publication date

1 October 2014

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Science Translational Medicine

21 February 2020

published in

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21 February 2020

volume

6

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21 February 2020

page(s)

258ra143

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issue

258

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The meta-genome of sepsis: host genetics, pathogens and the acute immune response

21 February 2020

cites work

1 reference

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PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment.

28 July 2018

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A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function

28 July 2018

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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes

28 July 2018

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28 July 2018

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28 July 2018

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Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine

28 July 2018

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Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels

28 July 2018

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Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism

28 July 2018

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Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

28 July 2018

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Effect of plasma phospholipid transfer protein deficiency on lethal endotoxemia in mice

28 July 2018

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S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products

28 July 2018

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Berberine decreases PCSK9 expression in HepG2 cells

28 July 2018

1 reference

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Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

28 July 2018

1 reference

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Molecular biology of PCSK9: its role in LDL metabolism

28 July 2018

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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

28 July 2018

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28 July 2018

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

28 July 2018

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A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis

28 July 2018

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men.

27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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Crossref

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21 January 2018

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12 December 2020

Continuation of Statin Therapy in Patients with Presumed Infection

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12 December 2020

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12 December 2020

Plasma PLTP (phospholipid-transfer protein): an emerging role in 'reverse lipopolysaccharide transport' and innate immunity

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12 December 2020

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Identifiers

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21 February 2020

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21 February 2020

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