Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity (Q35126395)

6 August 2017

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity (English)

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6 August 2017

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6

P Froguel

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6 August 2017

2

K Clement

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6 August 2017

4

S Hercberg

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6 August 2017

C Vaisse

1

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6 August 2017

E Durand

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3

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6 August 2017

B Guy-Grand

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5

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6 August 2017

language of work or name

English

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publication date

1 July 2000

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Journal of Clinical Investigation

6 August 2017

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6 August 2017

106

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6 August 2017

253-262

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6 August 2017

2

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Annual Deaths Attributable to Obesity in the United States

6 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Identification and molecular characterization of a small 11q23.3 de novo duplication in a patient with Rett syndrome manifestations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

A frameshift mutation in human MC4R is associated with a dominant form of obesity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

A frameshift mutation in MC4R associated with dominantly inherited human obesity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Assignment of the melanocortin 4 receptor (MC4R) gene to human chromosome band 18q22 by in situ hybridisation and radiation hybrid mapping

13 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

13 July 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU.VI.MAX study--design, methods, and participant characteristics. SUpplementation en VItamin

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Overexpression of Agrt leads to obesity in transgenic mice.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Deletions of the N-terminal regions of the human melanocortin receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Congenital leptin deficiency is associated with severe early-onset obesity in humans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Differential signal transduction by five splice variants of the PACAP receptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

The rapid detection of unknown mutations in nucleic acids.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Human placental protein 14 gene: sequence and characterization of a short duplication

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

The disease burden associated with overweight and obesity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

A leptin missense mutation associated with hypogonadism and morbid obesity.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314306

The spread of the obesity epidemic in the United States, 1991-1998

27 September 2018

1 reference

12 December 2020

Haplosufficiency of the melancortin-4 receptor gene in individuals with deletions of 18q

1 reference

12 December 2020

A short questionnaire for the measurement of habitual physical activity in epidemiological studies

1 reference

12 December 2020

Body Mass Index variations: centiles from birth to 87 years

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12 December 2020

Association of poorly controlled diabetes with low serum leptin in morbid obesity

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12 December 2020

Environmental contributions to the obesity epidemic

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12 December 2020

The Search for Human Obesity Genes

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12 December 2020

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

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12 December 2020

Identification and functional analysis of novel human melanocortin-4 receptor variants

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12 December 2020

Identifiers

DOI

10.1172/JCI9238

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6 August 2017

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6 August 2017

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