Targets for pharmacological intervention of endothelial hyperpermeability and barrier function (Q35127984)

6 August 2017

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title

Targets for pharmacological intervention of endothelial hyperpermeability and barrier function (English)

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6 August 2017

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Geerten P van Nieuw Amerongen

series ordinal

1

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6 August 2017

Victor W M van Hinsbergh

series ordinal

2

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6 August 2017

publication date

1 November 2002

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6 August 2017

published in

Vascular Pharmacology

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6 August 2017

volume

39

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6 August 2017

issue

4-5

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6 August 2017

page(s)

257-272

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Intra-arterial delivery of p53-containing adenoviral vector into experimental brain tumors

6 August 2017

cites work

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Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice

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7 January 2021

Steps toward mapping the human vasculature by phage display.

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7 January 2021

Therapeutic inhibition of the complement system. Y2K update

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7 January 2021

The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor

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7 January 2021

Regulation of vascular permeability by vascular endothelial growth factors.

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7 January 2021

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

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7 January 2021

Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury

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7 January 2021

Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering

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7 January 2021

Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood-brain barrier during ischaemia.

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7 January 2021

Building better vasculature

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7 January 2021

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

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7 January 2021

C1-inhibitor deficiency and angioedema.

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7 January 2021

Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats

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7 January 2021

Activation of rho is involved in the mechanism of hydrogen-peroxide-induced lung edema in isolated perfused rabbit lung

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7 January 2021

Cytotoxic chemotherapy: advances in delivery, pharmacology, and testing

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7 January 2021

A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability.

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7 January 2021

Pharmacological blood-brain barrier modification for selective drug delivery

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7 January 2021

Alterations in endothelial F-actin microfilaments in rabbit aorta in hypercholesterolemia

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7 January 2021

Measurement of albumin permeability across endothelial monolayers in vitro

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7 January 2021

A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability

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7 January 2021

Modifying leukocyte endothelial interactions in acute inflammatory models

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7 January 2021

Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Simvastatin, capillary permeability, and acetylcholine-mediated vasomotion in atherosclerotic, hypercholesterolemic men

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

High transcytosis of melanotransferrin (P97) across the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Attenuation of lung inflammation by adrenergic agonists in murine acute lung injury

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Treatment of porcine sepsis with high-dose antithrombin III reduces tissue edema and effusion but does not increase risk for bleeding

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Control of systemic capillary leak syndrome with aminophylline and terbutaline

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Therapy of microcirculatory disorders in severe acute pancreatitis: what mediators should we block?

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Effect of angiotensin II on immunotoxin uptake in tumor and normal tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Regulation of endothelial cell shape and barrier function by chromogranin A.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Soluble L-selectin attenuates tumor necrosis factor-alpha-mediated leukocyte adherence and vascular permeability: a protective role for elevated soluble L-selectin in sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Therapeutic angiogenesis in the ischemic canine heart induced by myocardial injection of naked complementary DNA plasmid encoding hepatocyte growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Effects of inhaled nitric oxide or inhibition of endogenous nitric oxide formation on hyperoxic lung injury

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

AE-941 (Neovastat): a novel multifunctional antiangiogenic compound

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Vascular pharmacology of acute lung injury and acute respiratory distress syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Vascular dysfunction in hyperglycemia: is protein kinase C the culprit?

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Calcium antagonists ameliorate ischemia-induced endothelial cell permeability by inhibiting protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Adrenomedullin reduces endothelial hyperpermeability

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Roles of bradykinin in vascular permeability and angiogenesis in solid tumor

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Leaky vessels? Call Ang1!

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Suppression of diabetic retinopathy with angiopoietin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Targeting complement in therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Norepinephrine and iloprost improve barrier function of human endothelial cell monolayers: role of cAMP

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Clinical use of TNF revisited: improving penetration of anti-cancer agents by increasing vascular permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Atrial natriuretic peptide regulation of endothelial permeability is mediated by cGMP

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Loss of placental growth factor protects mice against vascular permeability in pathological conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Angiogenesis and remodeling of airway vasculature in chronic inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Anti-inflammatory therapy for acute lung injury. A review of animal and clinical studies

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Transfer of low density lipoprotein into the arterial wall and risk of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Effect of factor XIII on endothelial barrier function.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

ATP induces dephosphorylation of myosin light chain in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

C1 esterase inhibitor concentrate for capillary leakage syndrome following bone marrow transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Hereditary angioedema: a broad review for clinicians

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

A highly selective inhibitor of Rho-associated coiled-coil forming protein kinase, Y-27632, prolongs cardiac allograft survival of the BALB/c-to-C3H/He mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Hypoxia and endothelin-1 induce VEGF production in human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Antithrombin III prevents and rapidly reverses leukocyte recruitment in ischemia/reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

A critical role of placental growth factor in the induction of inflammation and edema formation

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Neurochemical coupled actions of transmitters in the microvasculature of the brain

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

The action of beta-receptors on microvascular endothelium or: is airways plasma exudation inhibited by beta-agonists?

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Endothelin-1 induces endothelial barrier failure in the cat hindlimb

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Effects of isoprenaline and cooling on histamine induced changes of capillary permeability in the rat hindquarter vascular bed.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Integrin signaling revisited

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

The role of cytokines and adhesion molecules in the development of inflammatory injury

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Vascular leakage stimulates phenotype alteration in ocular cells, contributing to the pathology of proliferative vitreoretinopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Cell phenotype as a target of drug therapy in chronic inflammatory diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Strategies for increasing drug delivery to the brain: focus on brain lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Role of phosphodiesterases in the regulation of endothelial permeability in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Angiopoietin-1 protects the adult vasculature against plasma leakage.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Activated neutrophils induce hyperpermeability and phosphorylation of adherens junction proteins in coronary venular endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Role of Ca2+ signaling in the regulation of endothelial permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Cytoskeletal effects of rho-like small guanine nucleotide-binding proteins in the vascular system

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Simvastatin improves disturbed endothelial barrier function.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Direct actions of endothelin-1 on single vessel hydraulic permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Phase I trial of lobradimil (RMP-7) and carboplatin in children with brain tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Rho GTPases and the regulation of endothelial permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Factor XIII prevents development of myocardial edema in children undergoing surgery for congenital heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Characteristics of histamine-induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Protein kinase signaling in the modulation of microvascular permeability

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

High-dose atrial natriuretic factor enhances albumin escape from the systemic but not the pulmonary circulation

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Cellular and molecular neurosurgery: pathways from concept to reality--part II: vector systems and delivery methodologies for gene therapy of the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

Pharmacokinetics of methotrexate in cerebrospinal fluid and serum after osmotic blood-brain barrier disruption in patients with brain lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1537-1891%2803%2900014-4

7 January 2021

10.1016/S1537-1891(03)00014-4

Identifiers

DOI

1 reference

6 August 2017

1 reference