Ophthalmic drug discovery (Q35140846)

6 August 2017

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title

Ophthalmic drug discovery (English)

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6 August 2017

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Abbot F Clark

1

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6 August 2017

Thomas Yorio

series ordinal

2

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6 August 2017

publication date

1 June 2003

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Nature Reviews Drug Discovery

6 August 2017

published in

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6 August 2017

volume

2

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6 August 2017

issue

6

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6 August 2017

page(s)

448-459

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BIOMEDICINE: Enhanced: A New Angle on Ocular Development

6 August 2017

cites work

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Genetic basis of glaucoma

31 March 2020

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Identification of a gene that causes primary open angle glaucoma.

31 March 2020

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Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure

31 March 2020

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Adult-onset primary open-angle glaucoma caused by mutations in optineurin

31 March 2020

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The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.

31 March 2020

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The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration.The AGIS Investigators

31 March 2020

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Advances in glaucoma therapeutics

31 March 2020

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Medical backgrounders: glaucoma.

31 March 2020

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Matrix metalloproteinases in disease and repair processes in the anterior segment.

31 March 2020

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Early changes in matrix metalloproteinases and inhibitors afterin vitrolaser treatment to the trabecular meshwork

31 March 2020

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Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells

31 March 2020

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Experimental glaucoma damage mechanism

31 March 2020

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Glaucomatous optic neuropathy: mechanisms of disease

31 March 2020

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Mechanisms of optic nerve damage in primary open angle glaucoma

31 March 2020

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Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma

31 March 2020

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Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma

31 March 2020

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An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy

31 March 2020

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Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells

31 March 2020

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Endothelin: is it a contributor to glaucoma pathophysiology?

31 March 2020

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Ocular actions of endothelins

31 March 2020

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Serum autoantibodies in patients with glaucoma

31 March 2020

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Physiological approaches to neuroprotection. boosting of protective autoimmunity

31 March 2020

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Comparison of intraocular pressure lowering by topical and systemic carbonic anhydrase inhibitors in the rabbit

31 March 2020

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Laser-induced primate glaucoma. I. Progression of cupping

31 March 2020

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Development of experimental chronic intraocular hypertension in the rabbit

31 March 2020

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A rat model of chronic pressure-induced optic nerve damage

31 March 2020

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Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice

31 March 2020

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Chronic ocular hypertension following episcleral venous occlusion in rats

31 March 2020

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Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of India ink.

31 March 2020

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Alpha-2 adrenergic receptor agonists are neuroprotective in experimental models of glaucoma.

31 March 2020

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Programmed cell death of retinal ganglion cells during experimental glaucoma

31 March 2020

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An in vivo model of chronic optic nerve ischemia: the dose-dependent effects of endothelin-1 on the optic nerve microvasculature

31 March 2020

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Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye.

31 March 2020

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Characterization of a transformed rat retinal ganglion cell line

31 March 2020

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Vascular endothelial growth factor and the eye: biochemical mechanisms of action and implications for novel therapies

31 March 2020

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Diabetic retinopathy: more than meets the eye.

31 March 2020

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A new view of diabetic retinopathy: a neurodegenerative disease of the eye.

31 March 2020

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Retinopathy in galactosemic dogs continues to progress after cessation of galactosemia.

31 March 2020

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Retinal metabolic abnormalities in diabetic mouse: comparison with diabetic rat.

31 March 2020

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Changing times for the management of diabetic retinopathy

31 March 2020

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Mechanisms for monitoring changes in retinal status following therapeutic intervention in diabetic retinopathy

31 March 2020

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The potential role of PKC beta in diabetic retinopathy and macular edema

31 March 2020

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Intravitreal triamcinolone acetonide inhibits choroidal neovascularization in a laser-treated rat model

31 March 2020

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Intravitreal triamcinolone for refractory diabetic macular edema

31 March 2020

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Mechanisms of age-related macular degeneration.

31 March 2020

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Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

31 March 2020

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An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

31 March 2020

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A role for local inflammation in the formation of drusen in the aging eye.

31 March 2020

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Levobetaxolol-induced Up-regulation of retinal bFGF and CNTF mRNAs and preservation of retinal function against a photic-induced retinopathy

31 March 2020

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Selective photoreceptor damage in albino rats using continuous blue light. A protocol useful for retinal degeneration and transplantation research

31 March 2020

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Assessing retinal neovascularization in an animal model of proliferative retinopathy

31 March 2020

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Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy

31 March 2020

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Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.

31 March 2020

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Efficacy of Prinomastat) (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization

31 March 2020

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Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1.

31 March 2020

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Response of experimental retinal neovascularization to thiazolidinediones

31 March 2020

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Essential role of growth hormone in ischemia-induced retinal neovascularization

31 March 2020

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Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration

31 March 2020

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Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment.

31 March 2020

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Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor

31 March 2020

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Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases

31 March 2020

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AL-3789: a novel ophthalmic angiostatic steroid

31 March 2020

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An update on photodynamic therapy in age-related macular degeneration

31 March 2020

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Molecular genetics of age-related macular degeneration

31 March 2020

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A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy

31 March 2020

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Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy

31 March 2020

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Identification of the gene responsible for Best macular dystrophy

31 March 2020

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A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy

31 March 2020

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Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration

31 March 2020

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Evaluation of the Best disease gene in patients with age-related macular degeneration and other maculopathies

31 March 2020

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Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model

31 March 2020

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Genetic animal models for retinal degeneration

31 March 2020

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Retinal degeneration mutants in the mouse

31 March 2020

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Animal models in research on retinal degenerations: past progress and future hope

31 March 2020

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Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa

31 March 2020

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AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse

31 March 2020

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Gene therapy for retinal and choroidal diseases

31 March 2020

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Update on ocular allergy treatment

31 March 2020

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Ocular allergy guidelines: a practical treatment algorithm

31 March 2020

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Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine

31 March 2020

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The treatment of dry eye.

31 March 2020

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Managing cystoid macular edema after cataract surgery

31 March 2020

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Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis

31 March 2020

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Intraocular pressure-raising potential of 1.0% rimexolone in patients responding to corticosteroids

31 March 2020

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Anterior ocular infections: an overview of pathophysiology and treatment

31 March 2020

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Opportunistic infections of the eye in immunocompromised patients

31 March 2020

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Fluoroquinolones: place in ocular therapy

31 March 2020

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Ocular preparations: the formulation approach

31 March 2020

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Cyclodextrins in eye drop formulations: enhanced topical delivery of corticosteroids to the eye.

31 March 2020

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Penetration enhancers and ocular bioadhesives: two new avenues for ophthalmic drug delivery.

31 March 2020

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Biodegradable polymers for ocular drug delivery

31 March 2020

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Transscleral drug delivery for posterior segment disease

31 March 2020

1 reference

31 March 2020

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Genetic linkage of familial open angle glaucoma to chromosome 1q21–q31

31 March 2020

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Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells

31 March 2020

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A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping

31 March 2020

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Analysis of myocilin mutations in 1703 glaucoma patients from five different populations

31 March 2020

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31 March 2020

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Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)

31 March 2020

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Variations in the myocilin gene in patients with open-angle glaucoma

31 March 2020

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Myocilin and glaucoma: facts and ideas.

31 March 2020

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Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function

31 March 2020

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Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain

31 March 2020

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Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor

31 March 2020

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A cellular assay distinguishes normal and mutant TIGR/myocilin protein

31 March 2020

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Incidence of age-related cataract over a 10-year interval: the Beaver Dam Eye Study.

31 March 2020

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Five year incidence of cataract surgery: the Blue Mountains Eye Study.

31 March 2020

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Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model

31 March 2020

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Efficacy and safety of memantine, an NMDA-type open-channel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey

31 March 2020

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Topically applied betaxolol attenuates ischaemia-induced effects to the rat retina and stimulates BDNF mRNA.

31 March 2020

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Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma

31 March 2020

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Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats

31 March 2020

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Characterization of RGS5 in regulation of G protein-coupled receptor signaling

31 March 2020

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Comparison of the ocular hypotensive effect of brimonidine, dorzolamide, latanoprost, or artificial tears added to timolol in glaucomatous monkey eyes.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

A current appreciation of sites for pharmacological intervention in allergic conjunctivitis: effects of new topical ocular drugs

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1106

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Dimensions Publication ID

6 August 2017

1037089888

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