Loss of PINK1 impairs stress-induced autophagy and cell survival (Q35153949)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24751806%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Loss of PINK1 impairs stress-induced autophagy and cell survival (English)

1 reference

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14 March 2020

0 references

2

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14 March 2020

Ulrich Brandt

9

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14 March 2020

author name string

Dajana Parganlija

1

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14 March 2020

Jorge Domínguez-Bautista

3

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14 March 2020

Miriam Hetzel

4

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14 March 2020

Suzana Gispert

5

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14 March 2020

Marthe A Chimi

6

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14 March 2020

Stefan Dröse

7

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14 March 2020

Sören Mai

8

1 reference

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14 March 2020

Georg Auburger

10

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14 March 2020

Marina Jendrach

11

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14 March 2020

language of work or name

English

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publication date

21 April 2014

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14 March 2020

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14 March 2020

volume

9

1 reference

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14 March 2020

issue

4

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14 March 2020

page(s)

e95288

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Creative Commons Attribution 4.0 International

14 March 2020

copyright license

start time

21 April 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3994056/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria

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Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation

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PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR.

13 July 2018

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13 July 2018

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Development and characterization of a new Parkinson's disease model resulting from impaired autophagy

13 July 2018

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Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease

13 July 2018

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Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

13 July 2018

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Bioenergetic consequences of PINK1 mutations in Parkinson disease

13 July 2018

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Restriction of trophic factors and nutrients induces PARKIN expression

13 July 2018

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PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

13 July 2018

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Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

13 July 2018

1 reference

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Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells

13 July 2018

1 reference

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Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice

13 July 2018

1 reference

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13 July 2018

Mechanisms of mitophagy

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PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells

13 July 2018

1 reference

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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

13 July 2018

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Chaperone-mediated autophagy markers in Parkinson disease brains

13 July 2018

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Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24

13 July 2018

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PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

13 July 2018

1 reference

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

13 July 2018

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

13 July 2018

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The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

13 July 2018

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Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress

13 July 2018

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

13 July 2018

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The mitochondrial kinase PINK1, stress response and Parkinson's disease

13 July 2018

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Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

13 July 2018

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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

13 July 2018

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Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration

13 July 2018

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PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

13 July 2018

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Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

13 July 2018

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FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation

13 July 2018

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Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells

13 July 2018

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

13 July 2018

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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

13 July 2018

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13 July 2018

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

13 July 2018

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Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells

13 July 2018

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

13 July 2018

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Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

13 July 2018

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Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

The role of autophagy during the early neonatal starvation period

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

Altered expression of autophagic genes in the peripheral leukocytes of patients with sporadic Parkinson's disease.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

PINK1-linked parkinsonism is associated with Lewy body pathology

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

Aging of different avian cultured cells: lack of ROS-induced damage and quality control mechanisms

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994056

A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24751806

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Simple assay of 0.1–1.0 pmol of ATP, ADP, and AMP in single somatic cells using purified luciferin luciferase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24751806

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0095288

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24751806%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24751806%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

24751806

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24751806%20AND%20SRC:MED&resulttype=core&format=json