Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission (Q24320327)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903852

regulation of cristae formation

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903850

negative regulation of cristae formation

1 reference

Gene Ontology release 2020-05-02

1 reference

Autophagy related 7

1 reference

PTEN induced kinase 1

1 reference

Microtubule associated protein 1 light chain 3 beta

1 reference

Parkin RBR E3 ubiquitin protein ligase

1 reference

autophagy of mitochondrion

1 reference

Journal of Biological Chemistry

1 reference

0 references

mitochondrial fission

1 reference

1

Ruben K Dagda

Ruben K

Dagda

1 reference

20 October 2023

6

Charleen T Chu

Charleen T

Chu

1 reference

20 October 2023

Salvatore J Cherra

2

Salvatore J 3rd

Cherra

1 reference

20 October 2023

Scott M Kulich

series ordinal

3

author given names

Scott M

author last names

Kulich

1 reference

20 October 2023

Anurag Tandon

series ordinal

4

author given names

Anurag

author last names

Tandon

1 reference

20 October 2023

David Park

series ordinal

5

author given names

David

author last names

Park

1 reference

20 October 2023

language of work or name

English

0 references

publication date

15 May 2009

0 references

published in

0 references

volume

284

0 references

page(s)

13843-55

0 references

issue

20

0 references

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2679485/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

The kinase domain of mitochondrial PINK1 faces the cytoplasm

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

19 March 2017

1 reference

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Selective degradation of mitochondria by mitophagy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

19 March 2017

1 reference

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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

19 March 2017

1 reference

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

19 March 2017

1 reference

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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

19 March 2017

1 reference

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19 March 2017

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

19 March 2017

1 reference

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

19 March 2017

1 reference

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Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

19 March 2017

1 reference

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

19 March 2017

1 reference

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

The PINK1/Parkin pathway regulates mitochondrial morphology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

7 April 2017

1 reference

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

7 April 2017

1 reference

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

7 April 2017

1 reference

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

7 April 2017

1 reference

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

7 April 2017

1 reference

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Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models

7 April 2017

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Autophagy in neuroprotection and neurodegeneration: A question of balance.

27 September 2017

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Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease

27 September 2017

1 reference

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells.

27 September 2017

1 reference

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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

27 September 2017

1 reference

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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.

27 September 2017

1 reference

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Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death

27 September 2017

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6-Hydroxydopamine induces mitochondrial ERK activation.

27 September 2017

1 reference

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Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

27 September 2017

1 reference

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C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

27 September 2017

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Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

27 September 2017

1 reference

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Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes

27 September 2017

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Parkinsonism genes: culprits and clues

27 September 2017

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Toxin-induced models of Parkinson's disease

27 September 2017

1 reference

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Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

PINK1 mutations are associated with sporadic early-onset parkinsonism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Autophagosome formation in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Mechanistic approaches to Parkinson's disease pathogenesis.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Autophagy in neurons: a review

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

27 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808515200

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808515200

Involvement of macroautophagy in the dissolution of neuronal inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808515200

Mitochondrial aberrations in mucolipidosis Type IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808515200

Metalloporphyrins improve the survival of Sod2-deficient neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808515200

Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808515200

Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808515200

Mitochondrial abnormalities in Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679485

The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19279012

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M808515200

1 reference

release_kndwpriy4bgkbhjkiovijs7d2e

1574865

Fatcat ID

0 references

1574865

1 reference

1 reference

1 reference