Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble (Q35162578)

6 August 2017

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title

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble (English)

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6 August 2017

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Martin J Humphries

1

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6 August 2017

Paul A McEwan

2

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6 August 2017

Stephanie J Barton

3

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6 August 2017

Patrick A Buckley

4

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6 August 2017

Jordi Bella

5

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6 August 2017

A Paul Mould

6

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6 August 2017

1 June 2003

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6 August 2017

8

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Trends in Biochemical Sciences

inferred from page(s)

published in

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6 August 2017

28

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6 August 2017

6

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6 August 2017

313-320

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Integrins: versatility, modulation, and signaling in cell adhesion

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

1 reference

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Coming to grips with integrin binding to ligands

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Integrins: bidirectional, allosteric signaling machines

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Conformational regulation of integrin structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Integrin activation takes shape

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Structural basis of collagen recognition by integrin alpha2beta1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergistic sites mediate adhesive function.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Molecular Basis of Ligand Recognition by Integrin α5β1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Mechanisms contributing to the activity of integrins on leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Probing chemical and conformational differences in the resting and active conformers of platelet integrin alpha(IIb)beta(3).

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Structural determinants of integrin recognition by talin

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Does the integrin alphaA domain act as a ligand for its betaA domain?

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Integrin cell adhesion receptors and the concept of agonism.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

A reevaluation of integrins as regulators of angiogenesis

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https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

The eighth FIII domain of human fibronectin promotes integrin alpha5beta1 binding via stabilization of the ninth FIII domain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

Predicted and experimental structures of integrins and beta-propellers

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2803%2900112-9

7 January 2021

10.1016/S0968-0004(03)00112-9

Identifiers

DOI

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6 August 2017

1 reference