Why are there no proven therapies for genetic mitochondrial diseases? (Q35162928)

6 August 2017

title

Why are there no proven therapies for genetic mitochondrial diseases? (English)

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6 August 2017

Peter W Stacpoole

1

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6 August 2017

publication date

13 May 2011

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6 August 2017

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6 August 2017

volume

11

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6 August 2017

issue

5

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6 August 2017

page(s)

679-685

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The Dichloroacetate Dilemma: Environmental Hazard versus Therapeutic Goldmine—Both or Neither?

6 August 2017

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13 July 2018

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13 July 2018

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Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III.

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity

13 July 2018

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13 July 2018

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Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders

13 July 2018

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New insights into structure and function of mitochondria and their role in aging and disease

13 July 2018

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13 July 2018

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13 July 2018

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Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study

13 July 2018

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13 July 2018

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13 July 2018

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Metabolism and function of coenzyme Q.

13 July 2018

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Mitochondria, oxidative damage, and inflammation in Parkinson's disease

13 July 2018

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Cerebellar ataxia and coenzyme Q10 deficiency

13 July 2018

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The effect of short-term dimethylglycine treatment on oxygen consumption in cytochrome oxidase deficiency: a double-blind randomized crossover clinical trial.

13 July 2018

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Coenzyme Q(10) and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits

13 July 2018

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A placebo-controlled crossover trial of creatine in mitochondrial diseases

13 July 2018

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Treatment of congenital lactic acidosis with dichloroacetate

13 July 2018

1 reference

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13 July 2018

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Sequence and organization of the human mitochondrial genome

13 July 2018

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Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy

13 July 2018

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Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy

13 July 2018

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The pharmacology of dichloroacetate

13 July 2018

1 reference

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A randomized trial of coenzyme Q10 in mitochondrial disorders

13 July 2018

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Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial

27 September 2018

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27 September 2018

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Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism

27 September 2018

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A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease

27 September 2018

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Familial cerebellar ataxia with muscle coenzyme Q10 deficiency

27 September 2018

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Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease

27 September 2018

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Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism?

27 September 2018

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12 December 2020

Dichloroacetate as treatment for congenital lactic acidosis

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12 December 2020

Treatment of mitochondrial myopathy due to complex III deficiency with vitamins K3 and C: A 31P-NMR follow-up study

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12 December 2020

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

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12 December 2020

The treatment of mitochondrial myopathies and encephalomyopathies

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12 December 2020

A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies

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12 December 2020

Pharmacokinetics, metabolism and toxicology of dichloroacetate

1 reference

12 December 2020

10.1016/J.MITO.2011.05.002

Identifiers

DOI

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6 August 2017

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6 August 2017

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