RNAi as a gene therapy approach (Q35164788)

6 August 2017

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title

RNAi as a gene therapy approach (English)

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6 August 2017

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Natasha J Caplen

1

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PubMed ID

12831363

6 August 2017

language of work or name

English

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publication date

1 July 2003

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Expert Opinion on Biological Therapy

6 August 2017

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6 August 2017

3

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6 August 2017

4

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6 August 2017

575-586

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Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences

6 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Consistent gene silencing in transgenic plants expressing a replicating potato virus X RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Initiation and maintenance of virus-induced gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): a role for nautilus in embryonic somatic muscle formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Double-stranded RNA induces mRNA degradation in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Double-stranded RNA specifically disrupts gene expression during planarian regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Silencing of developmental genes in Hydra

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA as a target and an initiator of post-transcriptional gene silencing in transgenic plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A species of small antisense RNA in posttranscriptional gene silencing in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Role for a bidentate ribonuclease in the initiation step of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Argonaute2, a link between genetic and biochemical analyses of RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

On the role of RNA amplification in dsRNA-triggered gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Cellular RNA-dependent RNA polymerase involved in posttranscriptional gene silencing has two distinct activity modes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Gene silencing in Caenorhabditis elegans by transitive RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A counterdefensive strategy of plant viruses: suppression of posttranscriptional gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Small RNAs correspond to centromere heterochromatic repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Establishment and maintenance of a heterochromatin domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

microRNAs: tiny regulators with great potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Micro-RNAs: small is plentiful

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

MicroRNAs: deviants no longer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

MicroRNA maturation: stepwise processing and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Endogenous and silencing-associated small RNAs in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Identification of novel genes coding for small expressed RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Identification of tissue-specific microRNAs from mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

New microRNAs from mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Control of developmental timing by micrornas and their targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

The double-stranded RNA-dependent protein kinase PKR: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Specific interference with gene function by double-stranded RNA in early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Interactions between double-stranded RNA regulators and the protein kinase DAI

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Ribonuclease activity and RNA binding of recombinant human Dicer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNAi: mammalian oocytes do it without RNA-dependent RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Analysis of gene function in somatic mammalian cells using small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Interference of hepatitis C virus RNA replication by short interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNAi functions in cultured mammalian neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Specific and potent RNA interference in terminally differentiated myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Small interfering RNA-mediated gene silencing in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Gene silencing using micro-RNA designed hairpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Effective expression of small interfering RNA in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Functional siRNA expression from transfected PCR products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Stable suppression of gene expression by RNAi in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Retrovirus-delivered siRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Retroviral delivery of small interfering RNA into primary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNAi in human cells: basic structural and functional features of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Tolerance for mutations and chemical modifications in a siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

siRNAs can function as miRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference may be more potent than antisense RNA in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Comparison of the Suppressive Effects of Antisense Oligonucleotides and siRNAs Directed Against the Same Targets in Mammalian Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference: the new somatic cell genetics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Mediation of the DCC apoptotic signal by DIP13 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Specific inhibition of bcr-abl gene expression by small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Down-regulation of Bcl-2-interacting protein BAG-1 confers resistance to anti-cancer drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Perspectives on the development of a molecularly targeted agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Cloned zebrafish by nuclear transfer from long-term-cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Modulation of HIV-1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference in adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Short interfering RNA confers intracellular antiviral immunity in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Inhibition of gammaherpesvirus replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Inhibition of viral gene expression and replication in mosquito cells by dsRNA-triggered RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Viral suppressors of RNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Small interfering RNA and gene silencing in transgenic mice and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

Germline transmission of RNAi in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.3.4.575

21 January 2018

Identifiers

DOI

10.1517/14712598.3.4.575

1 reference

6 August 2017

1 reference

PubMed ID

12831363