Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1 (Q35168438)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25761126%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1 (English)

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2 March 2020

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3

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2 March 2020

William S Hlavacek

4

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2 March 2020

Tomasz Lipniacki

5

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2 March 2020

author name string

Paulina Szymańska

1

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2 March 2020

Katie R Martin

2

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2 March 2020

language of work or name

English

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publication date

11 March 2015

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2 March 2020

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2 March 2020

volume

10

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2 March 2020

issue

3

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2 March 2020

page(s)

e0116550

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Creative Commons Attribution 4.0 International

2 March 2020

copyright license

start time

11 March 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

28 July 2018

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Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.

28 July 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

28 July 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

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Termination of autophagy and reformation of lysosomes regulated by mTOR

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

28 July 2018

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

28 July 2018

1 reference

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Characterization of the FKBP.rapamycin.FRB ternary complex

28 July 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

28 July 2018

1 reference

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Control of stochasticity in eukaryotic gene expression

28 July 2018

1 reference

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Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

28 July 2018

1 reference

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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Noise in eukaryotic gene expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Regulation of noise in the expression of a single gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Construction of a genetic toggle switch in Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Strategy revealing phenotypic differences among synthetic oscillator designs.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Where is mTOR and what is it doing there?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

ZKSCAN3 is a master transcriptional repressor of autophagy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Eaten alive: a history of macroautophagy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

TSC2 mediates cellular energy response to control cell growth and survival

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4356596

10.1371/JOURNAL.PONE.0116550

27 September 2018

Identifiers

DOI

1 reference

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2 March 2020

0 references

0 references

1 reference

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2 March 2020

PubMed publication ID

25761126

1 reference

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