A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations. (Q35168968)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25624324%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations (English)

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28 February 2020

3

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28 February 2020

Klaus Korn

4

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28 February 2020

author name string

Corina Hutterer

1

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28 February 2020

Jan Eickhoff

2

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28 February 2020

Isabel Zeitträger

5

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28 February 2020

Hanife Bahsi

6

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28 February 2020

Sabrina Wagner

7

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28 February 2020

Gunther Zischinsky

8

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28 February 2020

Alexander Wolf

9

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28 February 2020

Carsten Degenhart

10

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28 February 2020

Anke Unger

11

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28 February 2020

Matthias Baumann

12

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28 February 2020

Bert Klebl

13

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28 February 2020

Manfred Marschall

14

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28 February 2020

language of work or name

English

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publication date

26 January 2015

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Antimicrobial Agents and Chemotherapy

28 February 2020

published in

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28 February 2020

volume

59

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28 February 2020

issue

4

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28 February 2020

page(s)

2062-2071

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Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.

28 February 2020

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Modification of the major tegument protein pp65 of human cytomegalovirus inhibits virus growth and leads to the enhancement of a protein complex with pUL69 and pUL97 in infected cells

27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapy

27 September 2018

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27 September 2018

Identifiers

DOI

10.1128/AAC.04534-14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25624324%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25624324%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25624324%20AND%20SRC:MED&resulttype=core&format=json