Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. (Q35172515)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636859%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃ (English)

1 reference

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2 February 2020

1 reference

Magdalena Chrzanowska-Wodnicka

7

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2 February 2020

author name string

Sribalaji Lakshmikanthan

1

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2 February 2020

Magdalena Sobczak

2

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2 February 2020

Changzoon Chun

3

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2 February 2020

Angela Henschel

4

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2 February 2020

Jillian Dargatz

5

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2 February 2020

Ramani Ramchandran

6

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2 February 2020

language of work or name

English

0 references

publication date

2 June 2011

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2 February 2020

1 reference

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2 February 2020

volume

118

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2 February 2020

page(s)

2015-2026

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2 February 2020

issue

7

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Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism

2 February 2020

cites work

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Regulation of angiogenesis by a small GTPase Rap1.

13 July 2018

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A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.

13 July 2018

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Control of cell adhesion dynamics by Rap1 signaling

13 July 2018

1 reference

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Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis

13 July 2018

1 reference

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Genetic and cell biological analysis of integrin outside-in signaling.

13 July 2018

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Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors

13 July 2018

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RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

13 July 2018

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Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke

13 July 2018

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Integrin and growth factor receptor alliance in angiogenesis

13 July 2018

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Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis

13 July 2018

1 reference

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E-cadherin dis-engagement activates the Rap1 GTPase

13 July 2018

1 reference

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Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions

13 July 2018

1 reference

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Integrins in angiogenesis and lymphangiogenesis

13 July 2018

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Integrin affinity modulation in angiogenesis

13 July 2018

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Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.

13 July 2018

1 reference

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Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis

13 July 2018

1 reference

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Cell-matrix adhesion in vascular development

13 July 2018

1 reference

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Targeting VEGF-A to treat cancer and age-related macular degeneration

13 July 2018

1 reference

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Integrin signaling is critical for pathological angiogenesis

13 July 2018

1 reference

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Angiogenesis in life, disease and medicine

13 July 2018

1 reference

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Angiogenesis in the mouse retina: a model system for experimental manipulation

13 July 2018

1 reference

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E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function

13 July 2018

1 reference

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Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions

13 July 2018

1 reference

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roundabout4 is essential for angiogenesis in vivo

13 July 2018

1 reference

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Rap1b is required for normal platelet function and hemostasis in mice

13 July 2018

1 reference

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RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

13 July 2018

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Endothelial-pericyte interactions in angiogenesis.

13 July 2018

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Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF

13 July 2018

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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

13 July 2018

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Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

13 July 2018

1 reference

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Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow

13 July 2018

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Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family

13 July 2018

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Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant

13 July 2018

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Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

13 July 2018

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Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

13 July 2018

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Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

13 July 2018

1 reference

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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

13 July 2018

1 reference

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

13 July 2018

1 reference

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Requirement of vascular integrin alpha v beta 3 for angiogenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158727

The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype

13 July 2018

1 reference

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Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1.

13 July 2018

1 reference

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NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways.

27 September 2018

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The sponge/Matrigel angiogenesis assay.

27 September 2018

1 reference

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Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

27 September 2018

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The selective regulation of alpha Vbeta 1 integrin expression is based on the hierarchical formation of alpha V-containing heterodimers

27 September 2018

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Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay

27 September 2018

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12 December 2020

Angiogenic network formation in the developing vertebrate trunk

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12 December 2020

Embryonic mesodermal defects in alpha 5 integrin-deficient mice

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12 December 2020

Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1

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12 December 2020

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Identifiers

DOI

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2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636859%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference