A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. (Q37420525)

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scientific article published on 26 August 2009

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English	A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.	scientific article published on 26 August 2009

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6 February 2020

A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis (English)

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Benjamin D Zeitlin

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Mark W Lingen

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Robert C Doebele

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Robert C Doebele

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Frank T Schulze-Hoepfner

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Jia Hong

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Alexandre Chlenski

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Kushboo Goel

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Suzana Gomes

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Yuru Liu

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Mark K Abe

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Jacques E Nor

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Marsha Rich Rosner

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26 August 2009

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4592-4600

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6 February 2020

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11 June 2022

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Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions

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Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.

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Epac proteins: multi-purpose cAMP targets

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Identifiers

10.1182/BLOOD-2009-04-217042

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6 February 2020

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6 February 2020

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