GGCX and VKORC1 inhibit osteocalcin endocrine functions. (Q35184466)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25753038%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

GGCX and VKORC1 inhibit osteocalcin endocrine functions (English)

1 reference

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2 March 2020

1 reference

4

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2 March 2020

author name string

Mathieu Ferron

1

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2 March 2020

Julie Lacombe

2

1 reference

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2 March 2020

Amélie Germain

3

1 reference

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2 March 2020

Gérard Karsenty

5

1 reference

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2 March 2020

language of work or name

English

0 references

publication date

9 March 2015

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2 March 2020

number of pages

16

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inferred from page(s)

published in

Journal of Cell Biology

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2 March 2020

volume

208

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2 March 2020

issue

6

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2 March 2020

page(s)

761-776

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25753038%20AND%20SRC:MED&resulttype=core&format=json

The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-arginine-based ER retention motif

2 March 2020

cites work

1 reference

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Regulation of energy metabolism by the skeleton: osteocalcin and beyond

13 July 2018

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Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation

13 July 2018

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Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis

13 July 2018

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Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration

13 July 2018

1 reference

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In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice

13 July 2018

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X-ray Crystal Structure of Bovine 3 Glu-Osteocalcin

13 July 2018

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Maternal and offspring pools of osteocalcin influence brain development and functions

13 July 2018

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Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a

13 July 2018

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VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy

13 July 2018

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Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis

13 July 2018

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Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells

13 July 2018

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The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus

13 July 2018

1 reference

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Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice

13 July 2018

1 reference

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Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-κB signaling pathway

13 July 2018

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Relationships between osteocalcin, glucose metabolism, and adiponectin in obese children: Is there crosstalk between bone tissue and glucose metabolism?

13 July 2018

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Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus

13 July 2018

1 reference

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Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism.

13 July 2018

1 reference

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Association of osteocalcin with obesity, insulin resistance, and cardiovascular risk factors in young adults

13 July 2018

1 reference

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The contribution of bone to whole-organism physiology

13 July 2018

1 reference

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Total and undercarboxylated osteocalcin predict changes in insulin sensitivity and β cell function in elderly men at high cardiovascular risk.

13 July 2018

1 reference

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Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight

13 July 2018

1 reference

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Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism

13 July 2018

1 reference

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Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice

13 July 2018

1 reference

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Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with beta-cell function

13 July 2018

1 reference

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GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo

13 July 2018

1 reference

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Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function

13 July 2018

1 reference

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Endocrine regulation of male fertility by the skeleton

13 July 2018

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Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition

13 July 2018

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Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism

13 July 2018

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An ELISA-based method to quantify osteocalcin carboxylation in mice

13 July 2018

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FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

13 July 2018

1 reference

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The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects

13 July 2018

1 reference

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Gamma-carboxylation of osteocalcin and insulin resistance in older men and women

13 July 2018

1 reference

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VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding

13 July 2018

1 reference

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The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity

13 July 2018

1 reference

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GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome

13 July 2018

1 reference

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Structure and function of vitamin K epoxide reductase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Endocrine regulation of energy metabolism by the skeleton

13 July 2018

1 reference

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The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on

13 July 2018

1 reference

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Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2

13 July 2018

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13 July 2018

1 reference

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Genes encoding vitamin-K epoxide reductase are present in Drosophila and trypanosomatid protists

13 July 2018

1 reference

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Identification of the gene for vitamin K epoxide reductase

13 July 2018

1 reference

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Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

13 July 2018

1 reference

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Bone recognition mechanism of porcine osteocalcin from crystal structure

13 July 2018

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Increased bone formation in osteocalcin-deficient mice.

13 July 2018

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A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

13 July 2018

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Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

13 July 2018

1 reference

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Excessive mineralization with growth plate closure in rats on chronic warfarin treatment

13 July 2018

1 reference

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Vitamin K-dependent carboxylation and vitamin K metabolism in liver. Effects of warfarin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone

13 July 2018

1 reference

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Normal carboxylation of circulating osteocalcin (bone Gla-protein) in Paget's disease of bone

13 July 2018

1 reference

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Purification and identification of bovine liver gamma-carboxylase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Osteocalcin is inversely associated with glucose levels in middle-aged Tibetan men with different degrees of glucose tolerance

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Reduced serum concentrations of carboxylated and undercarboxylated osteocalcin are associated with risk of developing type 2 diabetes mellitus in a high cardiovascular risk population: a nested case-control study

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

The serum undercarboxylated osteocalcin level and the diet of a Japanese population: results from the Kyushu and Okinawa Population Study (KOPS).

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Serum osteocalcin is not associated with glucose but is inversely associated with leptin across generations of nondiabetic women

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus.

27 September 2018

1 reference

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Isolation and culture of rodent osteoprogenitor cells

27 September 2018

1 reference

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Insulin sensitivity and the insulin-like growth factor system in prepubertal boys with premature adrenarche

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4362468

Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats.

27 September 2018

1 reference

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Bone embedding in pure methyl methacrylate at low temperature preserves enzyme activities

27 September 2018

1 reference

12 December 2020

Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches

1 reference

12 December 2020

Serum concentrations of carboxylated osteocalcin are increased and associated with several components of the polycystic ovarian syndrome

1 reference

12 December 2020

The effect of acute exercise on undercarboxylated osteocalcin in obese men

1 reference

12 December 2020

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

1 reference

12 December 2020

Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice

1 reference

12 December 2020

Calcium-dependent alpha-helical structure in osteocalcin

1 reference

12 December 2020

The effect of Pb(2+) on the structure and hydroxyapatite binding properties of osteocalcin

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.201409111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25753038%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25753038%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

PubMed publication ID

25753038

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25753038%20AND%20SRC:MED&resulttype=core&format=json