7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents (Q35190660)

7 August 2017

title

7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents (English)

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7 August 2017

6

Yves Pommier

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7 August 2017

Evgeny Kiselev

1

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7 August 2017

Sean DeGuire

2

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7 August 2017

Andrew Morrell

3

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7 August 2017

Keli Agama

4

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7 August 2017

Thomas S Dexheimer

5

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7 August 2017

Mark Cushman

7

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7 August 2017

language of work or name

English

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publication date

8 August 2011

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Journal of Medicinal Chemistry

7 August 2017

published in

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7 August 2017

volume

54

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7 August 2017

issue

17

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7 August 2017

page(s)

6106-6116

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describes a project that uses

7 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3165090/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The binding orientation of a norindenoisoquinoline in the topoisomerase I-DNA cleavage complex is primarily governed by pi-pi stacking interactions

13 July 2018

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Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

13 July 2018

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13 July 2018

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Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors

13 July 2018

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Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures

13 July 2018

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13 July 2018

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Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

13 July 2018

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13 July 2018

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Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

27 September 2018

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Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB.

27 September 2018

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Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors

27 September 2018

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https://pubmed.ncbi.nlm.nih.gov/21823606

12 December 2020

inferred from PubMed ID database lookup

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21823606

12 December 2020

inferred from PubMed ID database lookup

Facile and convenient syntheses of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin- 5-ones and 6,11-dihydro-5H-indolo[3,2-c]isoquinolin-5-one

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21823606

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/JM200719V

1 reference

7 August 2017

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7 August 2017

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