Topoisomerase I inhibitors: camptothecins and beyond (Q29614976)

Europe PubMed Central

title

Topoisomerase I inhibitors: camptothecins and beyond (English)

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30 April 2017

author name string

Pommier Y

series ordinal

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16990856

30 April 2017

language of work or name

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30 April 2017

publication date

October 2006

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30 April 2017

published in

Nature Reviews Cancer

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30 April 2017

volume

6

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30 April 2017

issue

10

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30 April 2017

page(s)

789-802

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Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

30 April 2017

cites work

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Essential functions of DNA topoisomerase I in Drosophila melanogaster

31 March 2020

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Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.

31 March 2020

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Human mitochondrial topoisomerase I

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Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases

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DNA topoisomerases: structure, function, and mechanism

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Cellular roles of dna topoisomerases: a molecular perspective

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Repair of topoisomerase I-mediated DNA damage

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A model for the mechanism of human topoisomerase I

31 March 2020

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8-Oxoguanine rearranges the active site of human topoisomerase I

31 March 2020

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

31 March 2020

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Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB.

31 March 2020

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Unveiling two distinct ribonuclease activities and a topoisomerase activity in a site-specific DNA recombinase

31 March 2020

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Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro

31 March 2020

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Recombinogenic flap ligation pathway for intrinsic repair of topoisomerase IB-induced double-strand breaks

31 March 2020

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Topoisomerase I-mediated DNA damage

31 March 2020

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Repair of and checkpoint response to topoisomerase I-mediated DNA damage

31 March 2020

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Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.

31 March 2020

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Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis

31 March 2020

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Induction of a Common Pathway of Apoptosis by Staurosporine

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DNA topoisomerase-targeting antitumor drugs can be studied in yeast

31 March 2020

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Topoisomerase I inhibitors: selectivity and cellular resistance.

31 March 2020

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Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin

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Non-camptothecin DNA topoisomerase I inhibitors in cancer therapy

31 March 2020

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Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

31 March 2020

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Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

31 March 2020

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Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles

31 March 2020

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Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay

31 March 2020

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Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

31 March 2020

1 reference

Specific interaction of camptothecin, a topoisomerase I inhibitor, with guanine residues of DNA detected by photoactivation at 365 nm

31 March 2020

1 reference

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

31 March 2020

1 reference

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

31 March 2020

1 reference

Mechanisms of camptothecin resistance by human topoisomerase I mutations

31 March 2020

1 reference

SV40 DNA replication intermediates: analysis of drugs which target mammalian DNA replication

31 March 2020

1 reference

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

31 March 2020

1 reference

Histone H2A variants H2AX and H2AZ

31 March 2020

1 reference

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

31 March 2020

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

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Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

31 March 2020

1 reference

Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage

31 March 2020

1 reference

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

31 March 2020

1 reference

Chk2 molecular interaction map and rationale for Chk2 inhibitors

31 March 2020

1 reference

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

31 March 2020

1 reference

Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

31 March 2020

1 reference

31 March 2020

Maintaining integrity

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Cell-cycle checkpoints and cancer

31 March 2020

1 reference

Checking on the fork: the DNA-replication stress-response pathway

31 March 2020

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DNA topoisomerase I is involved in both repression and activation of transcription

31 March 2020

1 reference

Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription

31 March 2020

1 reference

Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.

31 March 2020

1 reference

The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription.

31 March 2020

1 reference

Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription

31 March 2020

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Transcriptional consequences of topoisomerase inhibition

31 March 2020

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Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells

31 March 2020

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Ribosome Formation is Blocked by Camptothecin, a Reversible Inhibitor of RNA Synthesis

31 March 2020

1 reference

Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications

31 March 2020

1 reference

DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation

31 March 2020

1 reference

Processing of topoisomerase I cleavable complexes into DNA damage by transcription.

31 March 2020

1 reference

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

31 March 2020

1 reference

Transcription-dependent degradation of topoisomerase I-DNA covalent complexes

31 March 2020

1 reference

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability

31 March 2020

1 reference

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

31 March 2020

1 reference

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

31 March 2020

1 reference

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

31 March 2020

1 reference

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

31 March 2020

1 reference

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

31 March 2020

1 reference

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

31 March 2020

1 reference

Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing

31 March 2020

1 reference

Camptothecin hypersensitivity in poly(adenosine diphosphate-ribose) polymerase-deficient cell lines.

31 March 2020

1 reference

The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.

31 March 2020

1 reference

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts

31 March 2020

1 reference

Molecular interaction maps of bioregulatory networks: a general rubric for systems biology

31 March 2020

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Targeting multidrug resistance in cancer

31 March 2020

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Multidrug resistance in cancer: role of ATP-dependent transporters

31 March 2020

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Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast.

31 March 2020

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Analysis of comptothecin resistance in yeast: relevance to cancer therapy

31 March 2020

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Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro

31 March 2020

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Phase I studies of imatinib mesylate combined with cisplatin and irinotecan in patients with small cell lung carcinoma

31 March 2020

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Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

31 March 2020

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

31 March 2020

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Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

31 March 2020

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Review of UCN-01 development: a lesson in the importance of clinical pharmacology

31 March 2020

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Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

31 March 2020

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

31 March 2020

1 reference

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

31 March 2020

1 reference

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

31 March 2020

1 reference

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage

31 March 2020

1 reference

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

1 reference

Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

31 March 2020

1 reference

Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells

31 March 2020

1 reference

NF-kappaB activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events

31 March 2020

1 reference

Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

31 March 2020

1 reference

Apoptosis induced by topoisomerase inhibitors

31 March 2020

1 reference

Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.

31 March 2020

1 reference

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

31 March 2020

1 reference

Interfacial inhibitors of protein-nucleic acid interactions

31 March 2020

1 reference

Structural basis for the regulation of tubulin by vinblastine

31 March 2020

1 reference

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

31 March 2020

1 reference

Enhanced sensitivity to camptothecin in ataxia-telangiectasia cells and its relationship with the expression of DNA topoisomerase I.

31 March 2020

1 reference

Isolation of camptothecin-sensitive chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group

31 March 2020

1 reference

S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

31 March 2020

1 reference

The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

31 March 2020

1 reference

Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells

31 March 2020

1 reference

Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.

31 March 2020

1 reference

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

31 March 2020

1 reference

Genomic instability in laminopathy-based premature aging

31 March 2020

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Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts

31 March 2020

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Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents

31 March 2020

1 reference

Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability

31 March 2020

1 reference

Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

31 March 2020

1 reference

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

31 March 2020

1 reference

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

31 March 2020

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Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents

31 March 2020

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DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiation-sensitive irs mutants: comparisons to ataxia-telangiectasia cells

31 March 2020

1 reference

Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3.

31 March 2020

1 reference

Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors

31 March 2020

1 reference

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Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

123272

Dimensions Publication ID

1028961158

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OpenCitations bibliographic resource ID

123272

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