Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation (Q35196630)

7 August 2017

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title

Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation (English)

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7 August 2017

Frauke Fehrmann

1

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7 August 2017

Laimonis A Laimins

series ordinal

2

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7 August 2017

language of work or name

English

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publication date

1 August 2003

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7 August 2017

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7 August 2017

22

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7 August 2017

33

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7 August 2017

5201-5207

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1206554

7 August 2017

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E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc

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Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle Arrest

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Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells

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Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype

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Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

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Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins

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Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

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Cell-specific modulation of papovavirus replication by tumor suppressor protein p53

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Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

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Molecular architecture of tight junctions

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p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7.

21 January 2018

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p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

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Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein

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The human papillomavirus (HPV)-6 and HPV-16 E5 proteins co-operate with HPV-16 E7 in the transformation of primary rodent cells

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Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

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Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer

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p53 and E2F-1 cooperate to mediate apoptosis

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Human papillomaviruses.

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Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas

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7 January 2021

Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells

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7 January 2021

The human papillomavirus type 16 E5 gene cooperates with the E7 gene to stimulate proliferation of primary cells and increases viral gene expression.

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7 January 2021

DNA sequence of the HPV-16 E5 ORF and the structural conservation of its encoded protein

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7 January 2021

The E2F transcription factor is a cellular target for the RB protein

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7 January 2021

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7 January 2021

PDZ proteins organize synaptic signaling pathways

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7 January 2021

Enhancement of EGF- and PMA-mediated MAP kinase activation in cells expressing the human papillomavirus type 16 E5 protein

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7 January 2021

Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

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7 January 2021

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

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7 January 2021

Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene

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7 January 2021

Specific interaction between HPV-16 E1-E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network

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7 January 2021

Characterization of events during the late stages of HPV16 infection in vivo using high-affinity synthetic Fabs to E4.

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7 January 2021

Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene

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7 January 2021

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

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7 January 2021

Human papillomavirus type 31 E5 protein supports cell cycle progression and activates late viral functions upon epithelial differentiation

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7 January 2021

The role of the E1 and E2 proteins in the replication of human papillomavirus type 31b.

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7 January 2021

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

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7 January 2021

Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins

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7 January 2021

Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family

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7 January 2021

Creation of human tumour cells with defined genetic elements

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7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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7 January 2021

Persistence of type-specific human papillomavirus infection among cytologically normal women

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7 January 2021

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Expression of the HPV E7 oncoprotein mimics but does not evoke a p53-dependent cellular DNA damage response pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Specific association of human telomerase activity with immortal cells and cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Telomerase activation by the E6 gene product of human papillomavirus type 16.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

A reassessment of the telomere hypothesis of senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206554

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.279.5349.349

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

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24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1101/GAD.828901

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1128/MCB.20.4.1436-1447.2000

Identifiers

DOI

10.1038/SJ.ONC.1206554

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Dimensions Publication ID

7 August 2017

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