Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically ill (Q35201872)

7 August 2017

title

Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically ill (English)

1 reference

7 August 2017

main subject

cognitive dysfunction

1 reference

5

E Wesley Ely

1 reference

7 August 2017

Alessandro Morandi

1

1 reference

7 August 2017

Christopher G Hughes

2

1 reference

7 August 2017

Timothy D Girard

3

1 reference

7 August 2017

Danny F McAuley

4

1 reference

7 August 2017

Pratik P Pandharipande

6

1 reference

7 August 2017

language of work or name

English

0 references

publication date

1 September 2011

1 reference

7 August 2017

1 reference

7 August 2017

volume

140

1 reference

7 August 2017

issue

3

1 reference

7 August 2017

page(s)

580-585

1 reference

Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD.

7 August 2017

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit

13 July 2018

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HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages

13 July 2018

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13 July 2018

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13 July 2018

The inflammatory reflex

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury

26 September 2018

1 reference

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Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168859

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168859

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses.

26 September 2018

1 reference

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26 September 2018

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Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168859

Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168859

Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.

26 September 2018

1 reference

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Withdrawal of cerivastatin induces monocyte chemoattractant protein 1 and tissue factor expression in cultured vascular smooth muscle cells

26 September 2018

1 reference

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Withdrawal of statin treatment abrogates stroke protection in mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168859

Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice

26 September 2018

1 reference

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Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease

26 September 2018

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Withdrawal of statins increases event rates in patients with acute coronary syndromes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168859

Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168859

C-reactive protein as a predictor of infarct expansion and cardiac rupture after a first Q-wave acute myocardial infarction

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21896517

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Serum C-reactive protein concentration in acute myocardial infarction and its relationship to mortality during 24 months of follow-up in patients under thrombolytic treatment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21896517

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21896517

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1378/CHEST.10-3065

1 reference

7 August 2017

1 reference

7 August 2017

1 reference