Small molecules that reactivate mutant p53. (Q35204556)

7 August 2017

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title

Small molecules that reactivate mutant p53. (English)

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7 August 2017

V J N Bykov

1

1 reference

PubMed ID

12932659

7 August 2017

G Selivanova

series ordinal

2

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PubMed ID

12932659

7 August 2017

K G Wiman

series ordinal

3

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7 August 2017

1 September 2003

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European Journal of Cancer

7 August 2017

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7 August 2017

39

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7 August 2017

13

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7 August 2017

1828-1834

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7 August 2017

Surfing the p53 network

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https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

ASPP proteins specifically stimulate the apoptotic function of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Solubility as a function of protein structure and solvent components

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https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Restoration by glycerol of p53-dependent apoptosis in cells bearing the mutant p53 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Mining the National Cancer Institute Anticancer Drug Discovery Database: cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

The p53-stabilizing compound CP-31398 enhances ultraviolet-B-induced apoptosis in a human melanoma cell line MMRU

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

An information-intensive approach to the molecular pharmacology of cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Rescuing the function of mutant p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

Protein folding and disease: a view from the first Horizon Symposium.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900454-4

7 January 2021

10.1016/S0959-8049(03)00454-4

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12932659