Rescuing the function of mutant p53. (Q30329984)

18 June 2017

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title

Rescuing the function of mutant p53. (English)

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18 June 2017

2

Fersht AR

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18 June 2017

Bullock AN

1

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PubMed ID

11900253

18 June 2017

language of work or name

English

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publication date

1 October 2001

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18 June 2017

Nature Reviews Cancer

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18 June 2017

1

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18 June 2017

68-76

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18 June 2017

1

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18 June 2017

The Hallmarks of Cancer

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7 January 2021

Emergence of genetic instability in children treated for leukemia.

1 reference

7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

7 January 2021

Strategies for manipulating the p53 pathway in the treatment of human cancer.

1 reference

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

1 reference

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

7 January 2021

p53: oncogene or anti-oncogene?

1 reference

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

7 January 2021

The loss of mdm2 induces p53-mediated apoptosis

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7 January 2021

Surfing the p53 network

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7 January 2021

Mutations in the p53 gene occur in diverse human tumour types

1 reference

7 January 2021

Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1

1 reference

7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

7 January 2021

Flexibility: the key to p53 function?

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7 January 2021

Definition of a consensus binding site for p53

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7 January 2021

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

1 reference

7 January 2021

Biochemical characterization of different conformational states of the Sf9 cell-purified p53His175 mutant protein

1 reference

7 January 2021

Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

1 reference

7 January 2021

Thermodynamic stability of wild-type and mutant p53 core domain

1 reference

7 January 2021

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

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7 January 2021

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

1 reference

7 January 2021

Structure-based rescue of common tumor-derived p53 mutants

1 reference

7 January 2021

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

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7 January 2021

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

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7 January 2021

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

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7 January 2021

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

7 January 2021

Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution

1 reference

7 January 2021

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

1 reference

7 January 2021

In vitro analysis of the dominant negative effect of p53 mutants

1 reference

7 January 2021

Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo

1 reference

7 January 2021

Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization

1 reference

7 January 2021

Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions

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7 January 2021

Allosteric activation of latent p53 tetramers

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7 January 2021

Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation

1 reference

7 January 2021

Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells

1 reference

7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 reference

7 January 2021

Regulation of p53 protein function through alterations in protein-folding pathways

1 reference

7 January 2021

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

1 reference

7 January 2021

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

7 January 2021

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

1 reference

7 January 2021

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

1 reference

7 January 2021

Activation of p53 in cervical carcinoma cells by small molecules.

1 reference

7 January 2021

Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015.

1 reference

7 January 2021

Mechanism-based target identification and drug discovery in cancer research

1 reference

7 January 2021

Small, but deadly: small-molecule inhibition of Bcl-2 homologue heterodimerization

1 reference

7 January 2021

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

1 reference

7 January 2021

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

1 reference

7 January 2021

Identification of genomic DNA sequences bound by mutant p53 protein (Gly245-->Ser) in vivo.

1 reference

7 January 2021

Binding of MAR-DNA elements by mutant p53: possible implications for its oncogenic functions

1 reference

7 January 2021

The function of PML in p53-dependent apoptosis

1 reference

7 January 2021

Regulation of p53 activity in nuclear bodies by a specific PML isoform

1 reference

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

7 January 2021

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

7 January 2021

Refined solution structure of the oligomerization domain of the tumour suppressor p53

1 reference

7 January 2021

Solution structure of the tetrameric minimum transforming domain of p53

1 reference

7 January 2021

Structure of the negative regulatory domain of p53 bound to S100B(betabeta)

1 reference

7 January 2021

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

7 January 2021

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 reference

7 January 2021

Identifiers

DOI

10.1038/35094077

1 reference

PubMed ID

11900253

Dimensions Publication ID

18 June 2017

0 references

1 reference

PubMed ID

11900253