Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence (Q35208201)

7 August 2017

Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence (English)

1 reference

7 August 2017

K Pandya

1

1 reference

7 August 2017

K Meeke

2

1 reference

7 August 2017

A G Clementz

3

1 reference

7 August 2017

A Rogowski

4

1 reference

7 August 2017

J Roberts

5

1 reference

7 August 2017

L Miele

6

1 reference

7 August 2017

K S Albain

7

1 reference

7 August 2017

C Osipo

8

1 reference

7 August 2017

language of work or name

English

0 references

publication date

16 August 2011

1 reference

British Journal of Cancer

7 August 2017

1 reference

7 August 2017

105

1 reference

7 August 2017

6

1 reference

7 August 2017

796-806

1 reference

describes a project that uses

7 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3171020/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/bjc.2011.321

0 references

cites work

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Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation

13 July 2018

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The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches

13 July 2018

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Targeting Notch to target cancer stem cells.

13 July 2018

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Therapeutic antibody targeting of individual Notch receptors

13 July 2018

1 reference

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Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

13 July 2018

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Aromatase resistance mechanisms in model systems in vivo

13 July 2018

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Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory breast cancer: final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study

13 July 2018

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The canonical Notch signaling pathway: unfolding the activation mechanism

13 July 2018

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Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab

13 July 2018

1 reference

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Breast cancer cells expressing stem cell markers CD44+ CD24 lo are eliminated by Numb-1 peptide-activated T cells.

13 July 2018

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HER-2 positive breast cancer: what else beyond trastuzumab-based therapy?

13 July 2018

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Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

13 July 2018

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Issues and controversies in the treatment of HER2 positive metastatic breast cancer

13 July 2018

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Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu

13 July 2018

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High-level JAG1 mRNA and protein predict poor outcome in breast cancer

13 July 2018

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Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling.

13 July 2018

1 reference

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Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression

13 July 2018

1 reference

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A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer

13 July 2018

1 reference

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Herceptin: mechanisms of action and resistance

13 July 2018

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High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

13 July 2018

1 reference

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Trastuzumab therapy for tamoxifen-stimulated endometrial cancer

13 July 2018

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Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy

13 July 2018

1 reference

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Notch in mammary gland development and breast cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

13 July 2018

1 reference

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Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

13 July 2018

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Mechanism of action of trastuzumab and scientific update

13 July 2018

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Biology of HER2 and its importance in breast cancer

13 July 2018

1 reference

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Notch signaling in mammary gland tumorigenesis

13 July 2018

1 reference

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Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trials

13 July 2018

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New adjuvant strategies for breast cancer: meeting the challenge of integrating chemotherapy and trastuzumab (Herceptin).

13 July 2018

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Untangling the ErbB signalling network

13 July 2018

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Dll4, a novel Notch ligand expressed in arterial endothelium

13 July 2018

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Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

13 July 2018

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Involvement of Notch1 in the development of mouse mammary tumors

13 July 2018

1 reference

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13 July 2018

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Jagged: a mammalian ligand that activates Notch1

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Humanization of an anti-p185HER2 antibody for human cancer therapy

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Notch-1 and notch-4 receptors as prognostic markers in breast cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

A role for notch signaling in stromal survival and differentiation during prostate development

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Advanced chemoresistant breast cancer responding to multidisciplinary treatment with hyperthermia, radiotherapy, and intraarterial infusion

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Paradoxical Action of Fulvestrant in Estradiol-Induced Regression of Tamoxifen-Stimulated Breast Cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171020

Chronic DLL4 blockade induces vascular neoplasms

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FBJC.2011.321

c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21847123

12 December 2020

inferred from PubMed ID database lookup

Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21847123

12 December 2020

inferred from PubMed ID database lookup

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21847123

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/BJC.2011.321

1 reference

7 August 2017

1 reference

7 August 2017

1 reference