Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha (Q35209149)

7 August 2017

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title

Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha (English)

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7 August 2017

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2

Harvey F Lodish

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7 August 2017

Hong Ruan

1

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7 August 2017

1 October 2003

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Cytokine and Growth Factor Reviews

7 August 2017

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7 August 2017

14

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7 August 2017

5

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7 August 2017

447-455

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Mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes.

7 August 2017

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin resistance in type 2 diabetes: role of fatty acids

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin resistance: definition and consequences

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Role of insulin resistance in human disease (syndrome X): an expanded definition

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Pathophysiology of insulin resistance in human disease.

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin resistance and its treatment by thiazolidinediones

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

PPAR gamma and the treatment of insulin resistance

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Glitazones: clinical effects and molecular mechanisms

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin resistance and insulin sensitizers

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Pathogenesis of NIDDM. A balanced overview

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin receptor knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Role of brain insulin receptor in control of body weight and reproduction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Protein tyrosine phosphatase-1B in diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

IRS proteins and the common path to diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin resistance as the core defect in type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Mechanisms of fatty acid-induced inhibition of glucose uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Effects of free fatty acids per se on glucose production, gluconeogenesis, and glycogenolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Free fatty acids, insulin resistance and lipoprotein metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

An endotoxin-induced serum factor that causes necrosis of tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Studies of endotoxin-induced decrease in lipoprotein lipase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Shock and tissue injury induced by recombinant human cachectin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Tumor necrosis factor receptor and Fas signaling mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Tumor necrosis factor alpha inhibits signaling from the insulin receptor

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https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Correlation between muscle glycogen synthase activity and in vivo insulin action in man.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Role of free fatty acids in glucose homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Interaction of non-esterified fatty acid and insulin in control of triacylglycerol secretion by Hep G2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Control of Hep G2-cell triacylglycerol and apolipoprotein B synthesis and secretion by polyunsaturated non-esterified fatty acids and insulin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Fatty acids and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Mechanism of free fatty acid-induced insulin resistance in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Effect of fatty acids on glucose production and utilization in man

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Influence of nicotinic acid on the rates of turnover and oxidation of plasma glucose in man

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Regulation of Non-esterified Fatty Acid and Glycerol Concentration by Insulin in Normal Individuals and Patients with Type 2 Diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Differences in insulin suppression of free fatty acid levels by gender and glucose tolerance status. Relation to plasma triglyceride and apolipoprotein B concentrations. Insulin Resistance Atherosclerosis Study (IRAS) Investigators.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Increased insulin suppression of plasma free fatty acid concentration in exercise-trained rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Antilipolytic action of insulin: role of cAMP phosphodiesterase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Overexpression of 1-acyl-glycerol-3-phosphate acyltransferase-alpha enhances lipid storage in cellular models of adipose tissue and skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

A novel serum protein similar to C1q, produced exclusively in adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

AdipoQ is a novel adipose-specific gene dysregulated in obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Disruption of adiponectin causes insulin resistance and neointimal formation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

Troglitazone Antagonizes Tumor Necrosis Factor-α-induced Reprogramming of Adipocyte Gene Expression by Inhibiting the Transcriptional Regulatory Functions of NF-κB

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900052-2

7 January 2021

10.1016/S1359-6101(03)00052-2

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12948526