Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivator (Q35209771)

7 August 2017

title

Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivator (English)

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7 August 2017

Thomas Linsky

1

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7 August 2017

Yun Wang

series ordinal

2

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7 August 2017

Walter Fast

series ordinal

3

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7 August 2017

publication date

1 January 2011

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ACS Medicinal Chemistry Letters

7 August 2017

published in

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7 August 2017

volume

2

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7 August 2017

issue

8

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7 August 2017

page(s)

592-596

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A fluopol-ABPP HTS assay to identify PAD inhibitors

7 August 2017

cites work

1 reference

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A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase

28 July 2018

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Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide

28 July 2018

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Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.

28 July 2018

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Disruption of methylarginine metabolism impairs vascular homeostasis

28 July 2018

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Ebselen induced C6 glioma cell death in oxygen and glucose deprivation

28 July 2018

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Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase.

28 July 2018

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Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

28 July 2018

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Ebselen: prospective therapy for cerebral ischaemia

28 July 2018

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Interaction of ebselen with glutathione S-transferase and papain in vitro

28 July 2018

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Molecular actions of Ebselen—an antiinflammatory antioxidant

28 July 2018

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Study of highly selective and efficient thiol derivatization using selenium reagents by mass spectrometry

28 July 2018

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Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.

26 September 2018

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Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.

26 September 2018

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A continuous spectrophotometric assay for dimethylarginine dimethylaminohydrolase

26 September 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

26 September 2018

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Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial

26 September 2018

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Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group

26 September 2018

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Peculiar spectroscopic and kinetic properties of Cys-47 in human placental glutathione transferase. Evidence for an atypical thiolate ion pair near the active site

26 September 2018

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12 December 2020

Ebselen-binding equilibria between plasma and target proteins

1 reference

12 December 2020

A classical enzyme active center motif lacks catalytic competence until modulated electrostatically

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12 December 2020

A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline

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12 December 2020

Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa

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12 December 2020

Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte

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12 December 2020

Identifiers

DOI

10.1021/ML2000824

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7 August 2017

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7 August 2017

1 reference