Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors. (Q35210379)

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10 March 2020

title

Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors (English)

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10 March 2020

6

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10 March 2020

Kevin N Dalby

8

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10 March 2020

author name string

Ramakrishna Edupuganti

1

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10 March 2020

Qiantao Wang

2

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10 March 2020

Clint D J Tavares

3

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10 March 2020

Catrina A Chitjian

4

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10 March 2020

James L Bachman

5

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10 March 2020

Eric V Anslyn

7

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language of work or name

English

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publication date

30 June 2014

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Bioorganic & Medicinal Chemistry

10 March 2020

published in

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volume

22

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issue

17

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10 March 2020

page(s)

4910-4916

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Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer

10 March 2020

cites work

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12 December 2020

Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase

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12 December 2020

Interplay between insulin and nutrients in the regulation of translation factors

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12 December 2020

Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines

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12 December 2020

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398

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12 December 2020

Elongation factor-2 kinase: its role in protein synthesis and autophagy

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12 December 2020

Diverse, high-quality test set for the validation of protein-ligand docking performance.

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12 December 2020

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

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12 December 2020

Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta

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12 December 2020

Empirical scoring functions for advanced protein-ligand docking with PLANTS.

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12 December 2020

Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists.

1 reference

12 December 2020

Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues

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12 December 2020

Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli.

1 reference

12 December 2020

1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor

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12 December 2020

Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence

1 reference

12 December 2020

Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact

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12 December 2020

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

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12 December 2020

High-throughput screens for eEF-2 kinase

1 reference

12 December 2020

Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells

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12 December 2020

Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation

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12 December 2020

Phosphorylation of eukaryotic elongation factor 2 in differentiating and proliferating HL-60 cells

1 reference

12 December 2020

Role of calmodulin-dependent phosphorylation of elongation factor 2 in the proliferation of rat glial cells

1 reference

12 December 2020

Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine.

1 reference

12 December 2020

Regulation of elongation factor-2 by multisite phosphorylation

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12 December 2020

Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells.

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12 December 2020

10.1016/J.BMC.2014.06.050

Identifiers

DOI

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release_v5v3oubwfjgmjinsvj7ogaghoa

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