Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity (Q35216278)

7 August 2017

title

Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity (English)

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7 August 2017

7

David R Jones

1 reference

7 August 2017

Prasad S Adusumilli

1

1 reference

7 August 2017

Leonid Cherkassky

2

1 reference

7 August 2017

Jonathan Villena-Vargas

3

1 reference

7 August 2017

Christos Colovos

4

1 reference

7 August 2017

Elliot Servais

5

1 reference

7 August 2017

Jason Plotkin

6

1 reference

7 August 2017

Michel Sadelain

8

1 reference

7 August 2017

language of work or name

English

0 references

publication date

1 November 2014

1 reference

Science Translational Medicine

7 August 2017

published in

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7 August 2017

volume

6

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7 August 2017

issue

261

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7 August 2017

page(s)

261ra151

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Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma

7 August 2017

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Discovery of mesothelin and exploiting it as a target for immunotherapy

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Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer

13 July 2018

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Mesothelin, a novel immunotherapy target for triple negative breast cancer

13 July 2018

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Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients.

13 July 2018

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Tissue and serum mesothelin are potential markers of neoplastic progression in Barrett's associated esophageal adenocarcinoma

13 July 2018

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13 July 2018

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Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor

13 July 2018

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Inducible apoptosis as a safety switch for adoptive cell therapy

13 July 2018

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13 July 2018

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Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

13 July 2018

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Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma

13 July 2018

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Pre-clinical mouse models of primary and metastatic pleural cancers of the lung and breast and the use of bioluminescent imaging to monitor pleural tumor burden

13 July 2018

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13 July 2018

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Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity

13 July 2018

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Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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26 September 2018

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26 September 2018

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26 September 2018

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Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression

26 September 2018

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Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3010162

Cytokine levels and systemic toxicity in patients undergoing isolated limb perfusion with high-dose tumor necrosis factor, interferon gamma, and melphalan

21 January 2018

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12 December 2020

Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer

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12 December 2020

Malignant mesothelioma

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12 December 2020

CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection

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12 December 2020

Intratumoral recombinant human interleukin-12 administration in head and neck squamous cell carcinoma patients modifies locoregional lymph node architecture and induces natural killer cell infiltration in the primary tumor

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12 December 2020

Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis

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12 December 2020

10.1126/SCITRANSLMED.3010162

Identifiers

DOI

1 reference

7 August 2017

1 reference

7 August 2017

1 reference